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4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid

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4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:SR1664
CAS:1338259-05-4
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:SR1664
CAS:1338259-05-4
Purity:98.02% Package:1mg;48USD|2mg;68USD|5mg;113USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:SR 1664
CAS:1338259-05-4
Purity:>=97%(HPLC) Package:$137.9/5mg;$177.9/10mg;$385.9/25mg;$682.9/50mg;$1137.9/100mg;Bulk package Remarks:97%(HPLC)
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel: +8613720134139
Email: orders@jknbiochem.com
Products Intro: Product Name:SR1664
CAS:1338259-05-4
Purity:0.98 Package:10G:100G
Company Name: Dalian Meilun Biotech Co., Ltd.  
Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Products Intro: Product Name:SR1664
CAS:1338259-05-4
Purity:>98%,BR Package:1MG Remarks:MB0591

4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid manufacturers

  • SR1664
  • SR1664 pictures
  • $48.00 / 1mg
  • 2024-11-19
  • CAS:1338259-05-4
  • Min. Order:
  • Purity: 98.02%
  • Supply Ability: 10g
4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid Basic information
Product Name:4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid
Synonyms:4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid;SR1664;IIJDFXNUWZTHIM-NRFANRHFSA-N;[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2,3-dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-;SR1664 >=98% (HPLC);Inhibitor,inhibit,HEK293T,F282,clash,SR1664,stereospecificity,PPAR,dependent,phosphorylation,SR-1664,S273,Peroxisome proliferator-activated receptors;SR1664, 10 mM in DMSO
CAS:1338259-05-4
MF:C33H29N3O5
MW:547.6
EINECS:
Product Categories:
Mol File:1338259-05-4.mol
4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid Structure
4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid Chemical Properties
Boiling point 828.8±65.0 °C(Predicted)
density 1.27±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble15mg/mL, clear
pka3.87±0.36(Predicted)
form powder
color white to beige
Safety Information
Risk Statements 53
WGK Germany 3
MSDS Information
4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid Usage And Synthesis
UsesSR 1664 is a PPARγ non-agonist, which blocks Cdk5-mediated phosphorylation.
DefinitionChEBI: [1,1'-biphenyl]-2-carboxylic acid, 4'-[[2,3-dimethyl-5-[[[(1s)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1h-indol-1-yl]methyl]- is an indolecarboxamide.
Biological ActivitySR1664 is a non-agonist PPARγ ligand and an inhibitor of Cdk5-mediated PPARγ phosphorylation. It has strong antidiabetic activity in two murine models of diabetes without the side effects normally asociated with the thiazolidinedione (TZD) antidiabetic PPARγ agonists. The TZD antidiabetics such as rosiglitazone and pioglitazone are full PPARγ agonists, but recent data have suggested th at their separate activity, inhibition of the the obesity-linked PPARγ phosphorylation by Cdk5, is likely the more important activity for antidiabetic action. SR1664 has an IC50 of 80 nM in a competitive binding assay, blocked the Cdk5-mediated phosphorylation of PPARγ in vitro with IC50 between 20 and 200 nM and exhibited no PPARγ agonist activity.
4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid Preparation Products And Raw materials
Tag:4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid(1338259-05-4) Related Product Information