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Product Name:CGP 20712 dihydrochloride
CAS:1216905-73-5
Purity:96% by HPLC Remarks:CGP 20712 dihydrochloride is a potent and selective β1-adrenoceptor antagonist (IC50 = 0.7 nM) with 10,000-fold selectivity over β2-adrenoceptors.
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Product Name:CGP 20712 dihydrochloride
CAS:1216905-73-5
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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Product Name:CGP20712Dihydrochloride
CAS:1216905-73-5
Purity:NULL Package:10mg;25mg Remarks:NULL
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Nantong QuanYi Biotechnology Co., Ltd
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| Products Intro: |
Product Name:CGP 20712 dihydrochloride
CAS:1216905-73-5
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，More
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| | CGP 20712 dihydrochloride Basic information |
| Product Name: | CGP 20712 dihydrochloride | | Synonyms: | 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy]-2-propanol dihydrochloride | | CAS: | 1216905-73-5 | | MF: | C23H26ClF3N4O5 | | MW: | 530.93 | | EINECS: | | | Product Categories: | | | Mol File: | 1216905-73-5.mol |  |
| | CGP 20712 dihydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≥16.25 mg/mL in H2O | | form | solid | | color | White to light yellow | | Water Solubility | Soluble to 50 mM in water |
| | CGP 20712 dihydrochloride Usage And Synthesis |
| Uses | CGP 20712 Dihydrochloride is a highly potent and selective β1-AR antagonist. | | Biological Activity | cgp 20712 dihydrochloride is a potent and selective antagonist of β1-adrenoceptor with ic50 value of 0.7 nm [1].β1-adrenoceptor is a g-protein coupled receptor and mediates uncoupling protein-1 (ucp1) gene expression induced by norepinephrine (ne) [2].cgp 20712 dihydrochloride is a potent and selective β1-adrenoceptor antagonist. in neocortical membranes, cgp 20712 a exhibited affinity for β1-adrenoceptor and β2-adrenoceptor with ic50 values of 0.7 and 6700 nm, respectively [1]. in brown adipocytes, cgp-20712a significantly inhibited ucp1 gene expression induced by ne. however, cgp-20712a had no effect on lipolysis. these results suggested that β1-adrenoceptor mediated ucp1 gene expression [2]. in ventricular membranes from rats, cgp 20712a (300 nm) completely occupied its high-affinity binding sites. in ventricular myocytes isolated from rats, cgp 20712a (10, 100, 1000 nm) didn’t cause the activation of adenylate cyclase mediated by β2-adrenoceptors, which suggested that β2-adrenoceptors were not present on rat ventricular myocytes [3]. in adult rat cardiac myocytes, cgp 20712a inhibited β1-ar-stimulated apoptosis, which was mediated by a camp-dependent mechanism [4]. | | storage | Desiccate at +4°C | | references | [1]. dooley dj, bittiger h, reymann nc. cgp 20712 a: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. eur j pharmacol, 1986, 130(1-2): 137-139.
[2]. chaudhry a, granneman jg. differential regulation of functional responses by beta-adrenergic receptor subtypes in brown adipocytes. am j physiol, 1999, 277(1 pt 2): r147-153.
[3]. kitagawa y, adachi-akahane s, nagao t. determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. br j pharmacol. 1995, 116(1): 1635-1643.
[4]. communal c, singh k, sawyer db, et al. opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive g protein. circulation, 1999, 100(22): 2210-2212. |
| | CGP 20712 dihydrochloride Preparation Products And Raw materials |
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