| Company Name: |
ShangHai Biochempartner Co.,Ltd
|
| Tel: |
177-54423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:CFI-401870
CAS:1430741-35-7
Purity:98% HPLC LCMS Package:100MG;1G
|
| Company Name: |
Hubei Kele Fine Chemical Co., Ltd
|
| Tel: |
027-59101668 19945030958 |
| Email: |
2881924765@qq.com |
| Products Intro: |
Product Name:CFI-401870
CAS:1430741-35-7
Purity:98% HPLC Package:5KG;1KG;100g;1g
|
CFI-401870 manufacturers
- CFI-401870
-
- $2500.00 / 100mg
-
2024-10-24
- CAS:1430741-35-7
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | CFI-401870 Basic information |
| Product Name: | CFI-401870 | | Synonyms: | CFI401870;CFI-401870;1H-Indazole-5-carboxamide, N-[(R)-cyclopropyl-2-pyridinylmethyl]-3-[4-[(3-endo)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]phenyl]- | | CAS: | 1430741-35-7 | | MF: | C30H31N5O2 | | MW: | 493.6 | | EINECS: | | | Product Categories: | | | Mol File: | 1430741-35-7.mol |  |
| | CFI-401870 Chemical Properties |
| Boiling point | 820.2±65.0 °C(Predicted) | | density | 1.345±0.06 g/cm3(Predicted) | | pka | 13.13±0.46(Predicted) |
| | CFI-401870 Usage And Synthesis |
| Description | CFI-401870 is a orally bioavailable, potent tyrosine threonine kinase (TTK) Inhibitor (TTK IC50 < 10 nM, HCT116 GI50 < 0.1 μM). CFI-401870 displayed low off-target activity (>500×), and microsomal stability (T(1/2) > 30 min). CFI-401870 recapitulated the phenotype of TTK RNAi, demonstrated in vivo tumor growth inhibition upon oral dosing, and was selected for preclinical evaluation. |
| | CFI-401870 Preparation Products And Raw materials |
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