CGP 37157
| 中文名称 | CGP 37157 |
|---|---|
| 中文同义词 | CGP-37157 CALBIOCHEM;CGP 37157,NA + -CA 2+交换抑制剂 |
| 英文名称 | 7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE |
| 英文同义词 | 7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE;CGP 37157;7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one;4,1-Benzothiazepin-2(3H)-one, 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-;7-chloro-5-(2-chlorophenyl)benzo[e][1,4]thiazepin-2(1H,3H,5H)-one;CGP-37157 - CAS 75450-34-9 - Calbiochem;1-benzothiazepine-2(3H)-one;7-Chloro-5-(2-chlorophenyl)-1 |
| CAS号 | 75450-34-9 |
| 分子式 | C15H11Cl2NOS |
| 分子量 | 324.22 |
| EINECS号 | |
| 相关类别 | Ion transporter and other ion channel;Signalling |
| Mol文件 | 75450-34-9.mol |
| 结构式 |  |
CGP 37157 性质
| 沸点 | 479.8±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.384±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥20mg/mL |
| 酸度系数(pKa) | 12.20±0.40(Predicted) |
| 形态 | 白色固体 |
| 颜色 | 白色 |
| 稳定性 | 可在-20°C下DMSO溶液保存长达3个月。 |
IC50: 0.8 μM (Na + /Ca 2+ exchanger)
CGP37157 (Compound XVI) is a potent, selective inhibitor of Na + /Ca 2+ exchanger, inhibiting the Na + -induced Ca 2+ -release from guinea-pig heart mitochondria, with an IC 50 of 0.8 μM. CGP37157 (10 μM) shows inhibitory effect on mitochondrial Na + /Ca 2+ exchanger in cortical neurons, modulates intracellular Ca 2+ levels via suppresssing voltage-gated calcium channels, and reduces NMDA-induced cytosolic and mitochondrial Ca 2+ overloads. CGP37157 (10 μM) also reduces NMDA-induced excitotoxicity, and such an effect is via attenuating mitochondrial damage and calpain activity in neurons. CGP37157 (10 μM) in combination with salinomycin significantly attenuates cell viability and increases apoptosis of FaDu and HLaC79 cells. Moreover, CGP37157 has no inhibitory effect on salinomycin tumor toxicity.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-15754 | CGP37157 | 1 mg | 250元 | |
| 2024/04/30 | HY-15754 | CGP 37157 CGP37157 | 75450-34-9 | 5mg | 500元 |