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| | HJC0197 Basic information |
| Product Name: | HJC0197 | | Synonyms: | HJC0197;5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-;HJC 0197
(HJC0197);HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor;6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile | | CAS: | 1383539-73-8 | | MF: | C19H21N3OS | | MW: | 339.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1383539-73-8.mol |  |
| | HJC0197 Chemical Properties |
| solubility | DMF: 10 mg/ml; DMF:PBS(pH7.2) (1:2): 0.2 mg/ml; DMSO: 5 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | HJC0197 Usage And Synthesis |
| Description | Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). HJC0197 is a cell-permeable inhibitor of Epac1 and Epac2 (IC50 = 5.9 μM for Epac2). It inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM, but has no effect on cAMP-induced type I and II PKA activity at this concentration. Pretreatment of HEK293 cells expressing either Epac1 or Epac2 with 10 μM HJC0197 completely blocks Epac-mediated phosphorylation of Akt. HJC0197 has been used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures. |
| | HJC0197 Preparation Products And Raw materials |
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