|
Product Name: | AZ9482 | Synonyms: | AZ9482;AZ 9482;AZ-9482;2-(4-(3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile;AZ9482,breast,AZ 9482,inhibit,poly ADP ribose polymerase,PARP,cancer,Inhibitor,AZ-9482;3-Pyridinecarbonitrile, 2-[4-[3-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]benzoyl]-1-piperazinyl]- | CAS: | 1825345-33-2 | MF: | C26H22N6O2 | MW: | 450.49 | EINECS: | | Product Categories: | | Mol File: | 1825345-33-2.mol | |
| AZ9482 Chemical Properties |
density | 1.34±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMF: 0.25mg/mL,DMSO: 0.15mg/mL | form | A crystalline solid | pka | 12.09±0.40(Predicted) | color | White to yellow |
| AZ9482 Usage And Synthesis |
Description | AZ9482 is a poly(ADP-ribose) polymerase (PARP) inhibitor (IC50s = 1, 1, 46, 640, 9, and 160 nM for PARP1, -2, -3, -6, TNKS1/PARP5a, and TNKS2, respectively). It induces centrosome declustering (EC50 = <18 nM) and a multipolar spindle phenotype in HeLa cells. AZ9482 inhibits the growth of OCI-LY19 diffuse large B cell lymphoma (DLBCL) cells (GI50 = 3 nM). |
| AZ9482 Preparation Products And Raw materials |
|