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| | UNC-2371A Basic information |
| Product Name: | UNC-2371A | | Synonyms: | UNC-2371A;(1r,4r)-4-(2-(2-cyclopropylethylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol;MRX-2843 (UNC2371);MRX-2843;UNC2371;UNC2371;MRX-2843;Cyclohexanol, 4-[2-[(2-cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans-;MRX-2843?(Synonyms: UNC2371 | | CAS: | 1429882-07-4 | | MF: | C29H40N6O | | MW: | 488.67 | | EINECS: | | | Product Categories: | | | Mol File: | 1429882-07-4.mol |  |
| | UNC-2371A Chemical Properties |
| Melting point | >137°C (dec.) | | Boiling point | 697.3±65.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) | | pka | 14.63±0.40(Predicted) | | form | Solid | | color | White to Pale Beige |
| | UNC-2371A Usage And Synthesis |
| Description | MRX-2843 is an inhibitor of Mer and FMS-like tyrosine kinase 3 (FLT3; IC50s = 1.3 and 1 nM, respectively). It also inhibits Axl and Tyro3 (IC50s = 15 and 17 nM, respectively). MRX-2843 (10-300 nM) inhibits Mer phosphorylation in MOLM-14 and MV4-11 acute myeloid leukemia (AML) cells and reduces clonal expansion of Kasumi-1 AML cells (IC50 = 143.5 nM). In vivo, MRX-2843 increases survival in NOMO-1 and MOLM-14 AML mouse xenograft models when administered at doses of 65 and 50 mg/kg, respectively. | | Uses | MRX-2843, is an orally available small-molecule inhibitor of both MERTK and FLT3. |
| | UNC-2371A Preparation Products And Raw materials |
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