BPH-1358
| 中文名称 | BPH-1358 |
|---|---|
| 中文同义词 | 化合物BPH-1358 |
| 英文名称 | [1,1'-Biphenyl]-4,4'-dicarboxamide,N4,N4'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2) |
| 英文同义词 | [1,1'-Biphenyl]-4,4'-dicarboxamide,N4,N4'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2);BPH-1358;BPH-1358 HCl;Bacterial,inhibit,Inhibitor,NSC 50460,NSC-50460,BPH-1358,BPH 1358,BPH1358;N4,N4'-bis(3-(4,5-dihydro-1H-imidazol-2-yl)phenyl)-[1,1'-biphenyl]-4,4'-dicarboxamide dihydrochloride |
| CAS号 | 5352-53-4 |
| 分子式 | C32H29ClN6O2 |
| 分子量 | 565.07 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 5352-53-4.mol |
| 结构式 |  |
BPH-1358 性质
| 熔点 | 330 °C |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | DMF: insol,DMSO: 1 mg/ml,乙醇: insol,PBS (pH 7.2): insol |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
BPH-1358 (NSC50460) 是一种有效的人 FPPS 和 UPPS 抑制剂，IC50 值分别为 1.8 μM 和 110 nM，在体外对金黄色葡萄球菌的 MIC 值大约为 250 ng/mL。
IC50: 1.8 μM (human bisphosphonate farnesyl diphosphate synthase); 100 nM (undecaprenyl diphosphate synthase)
BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS) with an IC 50 of 110 nM. BPH-1358 against E. coli and S. aureus with EC 50 of 300 nM and 290 nM, respectively.
BPH-1358 is active against S. aureus in vivo (20/20 mice survived in an i.p. infection model with a MRSA strain).