8-BROMO-2,3,4,5-TETRAHYDRO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL HYDROBROMIDE
中文名称 | 8-BROMO-2,3,4,5-TETRAHYDRO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL HYDROBROMIDE |
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中文同义词 | 化合物SKF-83566 |
英文名称 | 8-BROMO-2,3,4,5-TETRAHYDRO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL HYDROBROMIDE |
英文同义词 | SKF 83566 HYDROBROMIDE;8-BROMO-2,3,4,5-TETRAHYDRO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL HYDROBROMIDE;(+/-)-SKF-83566 HYDROCHLORIDE SELECTIVE DOPAMINE D1;(±)-SCH-24543, (±)-7-Bromo-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride;1H-3-Benzazepin-7-ol, 8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-;8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol;159021;SKF 83566 hydrobromi |
CAS号 | 99295-33-7 |
分子式 | C17H18BrNO |
分子量 | 332.23 |
EINECS号 | 604-604-1 |
相关类别 | Dopamine receptor |
Mol文件 | 99295-33-7.mol |
结构式 | ![]() |
8-BROMO-2,3,4,5-TETRAHYDRO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL HYDROBROMIDE 性质
储存条件 | Desiccate at RT |
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溶解度 | 45%(w/v)aq2-羟丙基-β-环糊精:≥14 mg/mL |
形态 | 固体 |
颜色 | 驼色 |
D 1 Receptor
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D 5 Receptor
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5-HT 2 Receptor 11 nM (Ki) |
SKF-83566 (0.1 μM-10 μM) causes a concentration-dependent increase in peak evoked extracellular DA concentration ([DA] o ) evoked by single-pulse stimulation, with a maximum 65% increase in peak evoked [DA] o with 5 μM. The EC 50 value of this effect of SKF-83566 is 1.3 μM.SKF-83566 inhibited [ 3 H]DA uptake with an IC 50 of 5.73 μM. Moreover, SKF-83566 more potently inhibits the binding of [ 3 H]CFT, a cocaine analog, with an IC 50 of 0.51 μM in [ 3 H]DA uptake and [ 3 H]CFT binding studies.Similarly, in LLc-PK-rDAT cell, SKF-83566 also inhibits [ 3 H]CFT binding with an IC 50 of 0.77 μM in LLc-PK-rDAT cell membrane preparations.
SKF 83566 hydrobromide (oral administration; 20 µg/mL; 7 days) alone has no effects on altering LTP (115%). However, combinnation of SKF 83566 and nicotine significantly blocks the enhancement of long-term synaptic potentiation (LTP) induced by pretreatment with nicotine (SKF 83566+nicotine+cocaine, 120%; nicotine+cocaine, 143%).
Animal Model: | Male C57BL6/J mice (6- to 9-wk-old) |
Dosage: | 20 µg/mL (Together with nicotine for 7 d, followed by the injection of cocaine) |
Administration: | Oral administration; 7 days |
Result: | Blocked nicotine and cocaine-induced facilitation of LTP. |
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2023/03/20 | HY-103430 | 8-BROMO-2,3,4,5-TETRAHYDRO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL HYDROBROMIDE SKF-83566 hydrobromide | 99295-33-7 | 5mg | 950元 |
2023/03/20 | HY-103430 | 8-BROMO-2,3,4,5-TETRAHYDRO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL HYDROBROMIDE SKF-83566 hydrobromide | 99295-33-7 | 10mg | 1500元 |