|
|
| | EOS-62353 Basic information |
| | EOS-62353 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 65 mg/mL (144.06 mM) | | form | Solid | | color | Light yellow to yellow |
| | EOS-62353 Usage And Synthesis |
| Description | GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. |
| | EOS-62353 Preparation Products And Raw materials |
|