N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide
中文名称 | N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide |
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中文同义词 | N-(2-氧代-2-((1,2,3,4-四氢萘-1-基)氨基)乙基)-[1,1'-联苯]-4-甲酰胺;化合物TAO KINASE INHIBITOR 1;N-(2-氧代-2-((1,2,3,4-四氢萘-1-基)氨基)乙基)-[1,1'-联苯]-4-甲酰胺;CP 43,TAOK抑制剂 |
英文名称 | N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide |
英文同义词 | N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide;N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]-4-phenylbenzamide;CP 43;TAOK inhibitor 43;N-[2-Oxo-2-(1,2,3,4-tetrahydro-1-naphthalenylamino)ethyl]-4-biphenylcarboxamide;N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide;[1,1'-Biphenyl]-4-carboxamide, N-[2-oxo-2-[(1,2,3,4-tetrahydro-1-naphthalenyl)amino]ethyl]-;CP 43,TAO Kinase inhibitor-1,MAP kinase kinase kinase, MEKK, MAPKKK,CP43,CP-43,inhibit,TAO Kinase inhibitor 1,MAP3K,Inhibitor,TAO Kinase inhibitor1 |
CAS号 | 850467-66-2 |
分子式 | C25H24N2O2 |
分子量 | 384.47 |
EINECS号 | |
相关类别 | |
Mol文件 | 850467-66-2.mol |
结构式 |
N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide 性质
沸点 | 673.2±54.0 °C(Predicted) |
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密度 | 1.22±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:100mM;乙醇:20 mM |
形态 | 固体 |
酸度系数(pKa) | 13.08±0.46(Predicted) |
颜色 | 白色至米白色 |
TAO Kinase inhibitor 1 (compound 43) 是一种选择性的、ATP 竞争性的 thousand-and-one amino acid kinases (TAOK) 抑制剂,针对 TAOK1 和 TAOK2 的 IC50s 分别为 11 nM 和 15 nM。TAO Kinase inhibitor 1 延迟有丝分裂以及诱导有丝分裂细胞死亡。
TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells.