- CIL56
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- $31.00 / 1mg
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2024-11-19
- CAS:300802-28-2
- Min. Order:
- Purity: 99.91%
- Supply Ability: 10g
- CIL56
-
- $1.00 / 1g
-
2019-12-26
- CAS:300802-28-2
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 200kg
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| Product Name: | CIL56 | | Synonyms: | CIL56;YAP1 inhibitor CA3;7-bis(piperidin-1-ylsulfonyl)fluoren-9-ylidene]hydroxylamine;N-[2;7-BIS(PIPERIDIN-1-YLSULFONYL)FLUOREN-9-YLIDENE]HYDROXYLAMINE;CA3;CIL 56;CIL-56;2,7-Bis-(piperidine-1-sulfonyl)-fluoren-9-one oxime;N-Hydroxy-2,7-bis(1-piperidinylsulfonyl)-9H-fluoren-9-imine;CA3 NEW;CIL56(CA3) | | CAS: | 300802-28-2 | | MF: | C23H27N3O5S2 | | MW: | 489.61 | | EINECS: | | | Product Categories: | | | Mol File: | 300802-28-2.mol |  |
| | CIL56 Chemical Properties |
| Boiling point | 741.7±70.0 °C(Predicted) | | density | 1.51±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml; Ethanol: 0.15 mg/ml | | form | A crystalline solid | | pka | 10.16±0.20(Predicted) | | color | White to off-white |
| | CIL56 Usage And Synthesis |
| Uses | CIL56 inhibits YAP/Tead transcriptional activity. Has anti-tumour effects on oesophageal adenocarcinoma with therapeutic potential in combination with 5-FU. Involved in ferroptosis, mediated by iron-dependent ROS. | | Biological Activity | CA3 is a potent and selective inhibitor of YAP1 (Hippo co-activator Yes-associated protein 1) th at inhibits YAP1 expression and transcriptional activity in esophageal adenocarcinoma (EAC) cell lines. CA3 potently inhibits growth, induces apoptosis in radiation resistant CSC (cancer stem cell) enriched EAC cells. It inhibits tumor growth of in xenograft model with no apparent toxicity. |
| | CIL56 Preparation Products And Raw materials |
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