866893-90-5
| 中文名称 | 866893-90-5 |
|---|---|
| 中文同义词 | 化合物AFTIN4;(R)-2-((6-(苄基(甲基)氨基)-9-异丙基-9H-嘌呤-2-基)氨基)丁醇;(2R)-2-[[9-异丙基-6-[甲基(苯甲基)氨基]-9H-嘌呤-2-基]氨基]-1-丁醇;化合物AFTIN4,10 MM DMSO 溶液;【进口原装】Aftin-4/866893-90-5;化合物:Aftin-4 CAS:866893-90-5;【进口原装】Aftin-4/866893-90-5;化合物：Aftin-4 CAS:866893-90-5 |
| 英文名称 | Aftin-4 |
| 英文同义词 | Aftin-4;AFTIN-4;AFTIN 4;AFTIN4;N6-methyl-(R)-roscovitine;1-Butanol, 2-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-;Aftin-4 >=98% (HPLC);(R)-2-((6-(Benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol;β-amyloid peptide,inhibit,Abeta,Amyloid-β,Aftin-4,Inhibitor;Aftin-4, 10 mM in DMSO |
| CAS号 | 866893-90-5 |
| 分子式 | C20H28N6O |
| 分子量 | 368.48 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 866893-90-5.mol |
| 结构式 |  |
866893-90-5 性质
| 储存条件 | -20°C |
|---|---|
| 溶解度 | 可溶于DMSO |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| InChI | 1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1 |
| InChIKey | YPYWONAECUVKHY-MRXNPFEDSA-N |
| SMILES | [n]1(c2nc(nc(c2nc1)N(Cc3ccccc3)C)N[C@@H](CO)CC)C(C)C |
Amyloid-β
Aftin-4 selectively and potently increases Aβ 1-42 in N2a cells, primary neurons, and brain lysates, with an EC 50 value around 30 μM.
Aftin-4 increases Aβ 1-42 levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD). Aftin-4 is administered at increasing doses, between 3 and 20 nmol/mouse, into the lateral ventricle and animals are sacrificed at various time points, between 3 to 14 days after injection. The hippocampus is dissected out the contents in Aβ 1-40 or Aβ 1-42 is determined using a mouse ELISA assay. Aftin-4 dose-dependently and significantly increases Aβ 1-42 content, up to +216% at the highest dose tested.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-111267 | 866893-90-5 Aftin-4 | 866893-90-5 | 2mg | 729元 |
| 2026/09/15 | HY-111267 | 866893-90-5 Aftin-4 | 866893-90-5 | 5mg | 1245元 |