1621884-22-7
中文名称 | 1621884-22-7 |
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中文同义词 | 化合物 T13852 |
英文名称 | AODDRWVLAXJCBA-UHFFFAOYSA-N |
英文同义词 | AODDRWVLAXJCBA-UHFFFAOYSA-N;PSI-7409 tetrasodium;2'-Deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate sodium salt;PSI 7409 tetrasodium,PSI7409 tetrasodium |
CAS号 | 1621884-22-7 |
分子式 | C10H17FN2NaO14P3 |
分子量 | 524.16 |
EINECS号 | |
相关类别 | |
Mol文件 | 1621884-22-7.mol |
结构式 | ![]() |
1621884-22-7 性质
储存条件 | Store at -20°C |
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形态 | 固体 |
颜色 | 白色至米白色 |
水溶解性 | Water : ≥ 125 mg/mL (211.11 mM) |
IC50: 1.6 μM (GT 1b_Con1), 2.8 μM (GT 2a_JFH1), 0.7 μM (GT 3a), 2.6 μM (GT 4a)
PSI-7409 tetrasodium is an active 5'-triphosphate metabolite, inhibiting HCV NS5B polymerases, with IC 50 s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively. PSI-7409 also weakly inhibits human DNA polymerase α, with an IC 50 of 550 μM, but shows no inhibition on DNA Pol β and γ. In clone A cells, the levels of PSI-7409 gradually increases to a maximum concentration of about 25 μM over a period of 48 h. PSI-7409 forms at a much faster rate in primary human hepatocytes, achieving a maximum intracellular concentration of ∼100 μM at 4 h and remains at that concentration for 48 h.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-15745A | 1621884-22-7 PSI-7409 tetrasodium | 1621884-22-7 | 1mg | 2600元 |
2024/04/30 | HY-15745A | 1621884-22-7 PSI-7409 tetrasodium | 1621884-22-7 | 5mg | 7800元 |