Bradykinin (2-9)
中文名称 | Bradykinin (2-9) |
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中文同义词 | 舒缓激肽片段2-9;去-精氨酰-血管舒缓激肽;BRADYKININ (2-9) (SYNONYMS: DES-ARG1-BRADYKININ);化合物BRADYKININ (2-9);缓激肽2-9;舒缓激肽2-9;缓激肽BRADYKININ(2-9);(S)-5-胍基-2-((S)-2-((S)-1-((S)-3-羟基-2-((S)-3-苯基-2-(2-((S)-1-((S)-吡咯烷-2-羰基)吡咯烷-2-甲酰胺基)乙酰胺基)丙酰胺基)丙酰)吡咯烷-2-甲酰胺基)-3-苯基丙酰胺基)戊酸 |
英文名称 | PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG |
英文同义词 | BRADYKININ, FRAGMENT 2-9;BRADYKININ (2-9);(DES-ARG1)-BRADYKININ;H-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-OH;PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG;PPGFSPFR;1-DE-L-ARGININE-BRADYKININ;L-Pro-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg-OH |
CAS号 | 16875-11-9 |
分子式 | C44H61N11O10 |
分子量 | 904.02 |
EINECS号 | |
相关类别 | 多肽;细胞信号和神经生物学;细胞生物学;Peptide;BradykininsPeptides and Proteins;Bradykinins;Neuropeptides;Peptides for Cell Biology |
Mol文件 | 16875-11-9.mol |
结构式 |
Bradykinin (2-9) 性质
密度 | 1.46±0.1 g/cm3(Predicted) |
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储存条件 | −20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 3.34±0.10(Predicted) |
形态 | 白色至类白色粉末。 |
颜色 | 白色至米白色 |
序列 | -Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH |
The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8).
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-P1490 | Bradykinin (2-9) | 1 mg | 457元 | |
2024/08/19 | HY-P1490 | PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG Bradykinin (2-9) | 16875-11-9 | 5mg | 780元 |