阿拉磷
中文名称 | 阿拉磷 |
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中文同义词 | 阿拉磷;L-丙氨酰-L-1-氨基乙基膦酸;化合物 T25021 |
英文名称 | (S)-ALANYL-(R)-1-AMINOETHYLPHOSPHONIC ACID |
英文同义词 | (S)-ALANYL-(R)-1-AMINOETHYLPHOSPHONIC ACID;L-ALANYL-L-1-AMINOETHYLPHOSPHONIC ACID;L-ALANYL-L-ALA(P)-OH;ALAFOSFALIN;ALAPHOSPHIN;(S)-Alanyl-(R)-1-aminoethylphosphonic acid, Alafosfalin, Alaphosphin;[(1R)-1-[[(2S)-2-Aminopropanoyl]amino]ethyl]phosphonic acid;L-ALANYL-L-ALA(P)-OH, (S)-ALANYL-(R)-1-AMINOETHYLPHOSPHONIC ACID |
CAS号 | 60668-24-8 |
分子式 | C5H13N2O4P |
分子量 | 196.14 |
EINECS号 | 262-362-8 |
相关类别 | |
Mol文件 | 60668-24-8.mol |
结构式 |
阿拉磷 性质
熔点 | 295-296° (dec) |
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比旋光度 | D20 -44.0° (c = 1 in H2O) |
密度 | 1.395±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 甲醇(少量溶解)、水(少量溶解) |
酸度系数(pKa) | 2.60±0.10(Predicted) |
形态 | 粉末 |
颜色 | 无色或白色 |
旋光性 (optical activity) | [α]20/D 45±2°, c = 1% in H2O |
Merck | 13,202 |
BRN | 4801790 |
Antibacterial
Alafosfalin is highly active against Escherichia coli and moderately active against Serratia , Klebsiella , Enterobacter , and Citrobacter , but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive Proteus , Pseudomonas , and Acinetobacter .
After s.c. administration to rats, Alafosfalin is rapidly absorbed with half-lives (t 1/2 ) of approximately 20 minutes.
Animal Model: | Pairs of male SpragueDawley rats (250 to 350 g) |
Dosage: | 20, 100, and 500 mg/ kg (single doses) or 800 mg/kg per day for 14 days (Pharmacokinetic Analysis) |
Administration: | Administrated by s.c. |
Result: | Rapidly absorbed; peak concentrations were found within 20 minutes of dosing with half-lives of approximately 20 minutes. |