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5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]pyridine

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5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]pyridine Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Products Intro: Product Name:MIND4-17
CAS:345989-24-4
Package:25mg;1520USD|50mg;1980USD|100mg;2500USD
Company Name: Alinda Chemical Ltd.  
Tel: +7 (495) 672-17-08
Email: sale@alinda.ru
Products Intro: CAS:345989-24-4
Package:1mg Remarks:C20H15N5O3S
Company Name: Energy Chemical  
Tel: 021-58432009 400-005-6266
Email: marketing@energy-chemical.com
Products Intro: Product Name:MIND4-17 >=98% (HPLC)
CAS:345989-24-4
Purity:NULL Package:1ea;25mg;5mg Remarks:NULL
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:MIND4-17
CAS:345989-24-4
Package:25mg/RMB 10600;50mg/RMB 13800;100mg/RMB 17500

5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]pyridine manufacturers

  • MIND4-17
  • MIND4-17 pictures
  • $1520.00 / 25mg
  • 2024-10-28
  • CAS:345989-24-4
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]pyridine Basic information
Product Name:5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]pyridine
Synonyms:5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]pyridine;Pyridine, 5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio]-;MIND4-17 >=98% (HPLC);MIND4-17
CAS:345989-24-4
MF:C20H15N5O3S
MW:405.43
EINECS:
Product Categories:
Mol File:345989-24-4.mol
5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]pyridine Structure
5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]pyridine Chemical Properties
Boiling point 667.5±65.0 °C(Predicted)
density 1.39±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 2mg/mL, clear (warmed)
form Solid
pka-0.38±0.10(Predicted)
color Off-white to light yellow
Safety Information
MSDS Information
5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]pyridine Usage And Synthesis
Biological ActivityMIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator th at covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1), the primary negative regulator of NRF2. MIND4-17 induces NRF2 activation responses in neuronal and non-neuronal cultures (effective conc. 0.1-10 μM) of human, mouse, and r at origins. In addition, MIND4-17 effectively reduces endotoxin-induced IL-6 release from WT as well as YAC128 HD mutant mice-derived primary microglia and astrocytes, however, NRF2 induction by MIND4-17 is shown to be compromised in human Huntingtonμs diseased (HD) relative to non-disesed neural stem cells due to suppressive influence of the expanded CAG repe at mutation on pathway activation.
5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]pyridine Preparation Products And Raw materials
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