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| | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Basic information |
| Product Name: | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea | | Synonyms: | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea;H151;H-151;H-151;H-151;STING ANTAGONIST;STING antagonist;N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea;H-151;H 151 NEW;Urea, N-(4-ethylphenyl)-N'-1H-indol-3-yl-;STING inhibitor | | CAS: | 941987-60-6 | | MF: | C17H17N3O | | MW: | 279.34 | | EINECS: | | | Product Categories: | | | Mol File: | 941987-60-6.mol |  |
| | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Chemical Properties |
| Boiling point | 399.9±25.0 °C(Predicted) | | density | 1.298±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in DMSO (25 mg/ml) | | form | solid | | pka | 14.96±0.70(Predicted) | | color | Off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Usage And Synthesis |
| Description | H-151 (941987-60-6) is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice. | | Uses | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea (cas# 941987-60-6) is a useful research chemical. It is used in biological studies in the enhancement of transgene expression by beta-catenin inhibitor iCRT14. | | storage | Store at +4°C | | References | 1) Haag et al. (2018), Targeting STING with covalent small-molecule inhibitors; Nature 559 269
2) Lee et al. (2019), STING restricts oHSV Replication and Spread in Resistant MPNSYs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation; Mol. Ther. Oncolytics 15 91 [FOCUS Citation] |
| | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Preparation Products And Raw materials |
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