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BOC Sciences
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1-631-485-4226; 16314854226 |
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Product Name:SKA-121
CAS:1820708-73-3
Purity:98% Remarks:SKA-121 is a positive-gating modulator of intermediate-conductance calcium-activated potassium channels (IKCa1/KCa3.1). It also activates KCa2.2 and KCa2.3 channels. In blood pressure telemetry experi
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SKA-121 manufacturers
- SKA-121
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- $82.00 / 2mg
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2024-10-24
- CAS:1820708-73-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | SKA-121 Basic information |
| Product Name: | SKA-121 | | Synonyms: | SKA-121;Naphth[2,1-d]oxazol-2-amine, 5-methyl-;SKA-121 5-Methylnaphtho[2,1-d]oxazol-2-amin;SKA121,SKA 121 | | CAS: | 1820708-73-3 | | MF: | C12H10N2O | | MW: | 198.22 | | EINECS: | | | Product Categories: | | | Mol File: | 1820708-73-3.mol |  |
| | SKA-121 Chemical Properties |
| Boiling point | 403.2±38.0 °C(Predicted) | | density | 1.302±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml | | form | powder | | pka | 4.48±0.30(Predicted) | | color | brown to dark gray |
| | SKA-121 Usage And Synthesis |
| Biochem/physiol Actions | SKA-121 is a KCa3.1 (IKCa1, IK1, KCa4, SKCa4, SK4) subtype-selective small conductance Ca2+-activated K+ channel (SK channel) positive-gating modulator (EC50 = 109 nM/KCa3.1 vs. 8.7 μM/KCa2.1, 6.8 μM/KCa2.2, 4.4 μM/KCa2.3) with 200- to 400-fold selectivity over CaV1.2 as well as representative KVs (KV1.3, KV2.1, KV3.1, and KV11.1) and NaV (NaV1.2, NaV1.4, NaV1.5, and NaV1.7) channels. When applied in vivo, SKA-121 significantly lowers mean arterial blood pressure in wild-type, but not KCa3.1(-/-), normotensive and hypertensive mice (100 mg/kg i.p.). SKA-121 is a more potent and selective KCa3.1 activator than SKA-31 (EC50 = 260 nM/KCa3.1, 2.9 μM/KCa2.1, 1.9 μM/KCa2.2, 2.9 μM/KCa2.3). | | storage | Store at -20°C |
| | SKA-121 Preparation Products And Raw materials |
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