| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:NCT-506
CAS:2231098-99-8
Purity:98% HPLC Package:100mg，250mg，1g
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:NCT-506;NCT 506,NCT506
CAS:2231098-99-8
Purity:98% Package:25 mg
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| | NCT-506 Basic information |
| Product Name: | NCT-506 | | Synonyms: | NCT-506;NCT 506,NCT506;Cyclopropanecarbonitrile, 1-[4-[6-fluoro-3-[[4-(methylsulfonyl)-1-piperazinyl]carbonyl]-4-quinolinyl]phenyl]- | | CAS: | 2231098-99-8 | | MF: | C25H23FN4O3S | | MW: | 478.54 | | EINECS: | | | Product Categories: | | | Mol File: | 2231098-99-8.mol |  |
| | NCT-506 Chemical Properties |
| Boiling point | 719.9±70.0 °C(Predicted) | | density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 33.33 mg/mL (69.65 mM; Need ultrasonic) | | pka | 3.74±0.27(Predicted) | | form | Solid | | color | White to off-white |
| | NCT-506 Usage And Synthesis |
| Biological Activity | NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC50 of 7 nM[1].
NCT-506 inhibits ALDH1A1, hALDH1A3, hALDH2 with IC50s of 0.007±0.001, 16.4±3.99, and 21.5 μM, respectively[1].NCT-506 (100, 10, 1, 0.1 μM, 6 days) decreases significantly cell viability with an EC50 of 45.6 μM in OV-90 cells. NCT-506 inhibits MIA PaCa-2, OV-90, and HT-29 cells with IC50s of 0.077±0.040, 0.161±0.038, and 0.048±0.022 μM in aldefluor cell-based assays, respectively[1]. NCT-506 is treated in combined with Paclitaxel, IC50s of 1202, 924, 870, 411, 102, and 31.8 nM with concentrations of NCT-506 at 0 (DMSO), 1, 3, 10, 20, 30 μM in SKOV-3-TR cells, respectively[1]. | | References | [1]. Yang SM, et al. Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity. J Med Chem. 2018 Jun 14;61(11):4883-4903. |
| | NCT-506 Preparation Products And Raw materials |
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