化合物 T12260
| 中文名称 | 化合物 T12260 |
|---|---|
| 中文同义词 | 化合物 T12260;化合物 NSC117079 |
| 英文名称 | NSC117079 |
| 英文同义词 | NSC117079;2-Anthracenesulfonic acid, 1-amino-4-[[3-(aminosulfonyl)phenyl]amino]-9,10-dihydro-9,10-dioxo-;NSC-117079,NSC117079 |
| CAS号 | 500363-63-3 |
| 分子式 | C20H15N3O7S2 |
| 分子量 | 473.48 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 500363-63-3.mol |
| 结构式 |  |
化合物 T12260 性质
| 密度 | 1.696±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：50 mg/mL（105.60 mM） |
| 酸度系数(pKa) | -1.19±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅紫色至紫色 |
PHLPP
NSC-117079 at 30 μM induces neutrophil adhesion to plated fibrinogen from 9.0±2.4% to 27.0±8.0% and enhanced neutrophil adhesion caused by 50 ng/mL GM-CSF from 22.9±6.0% to 47.6±10.9%. Neutrophil adhesion is followed by neutrophil transendothelial migration. Results suggest that PHLPP inhibitor NSC-117079 is effective in preventing Akt from dephosphorylation in neutrophils, and Akt phosphatase PHLPP serves to attenuate neutrophil adhesion but not migration.
A single intraarticular injection of the Phlpp inhibitor NSC117079 attenuates mechanical allodynia and slows articular cartilage degradation in joints with a destabilized meniscus. Animals treated with the Phlpp inhibitor seven weeks after injury maintain normal activity levels, while those in the control group travel shorter distances and are less active three months after the joint injury. NSC117079 also increases production of cartilage extracellular matrix components (glycosaminoglycans and aggrecan) in over 90% of human articular cartilage explants from osteoarthritis patients and increased phosphorylation of Phlpp1 substrates (AKT2, ERK1/2 and PKC) in human articular chondrocytes.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-19819 | NSC117079 | 1 mg | 863元 | |
| 2024/08/19 | HY-19819 | 化合物 T12260 NSC117079 | 500363-63-3 | 5mg | 1600元 |