| Company Name: |
Jingmo (Xiamen) Biotechnology Co., Ltd Gold
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| Tel: |
13621943973 13515979683 |
| Email: |
sales@jamxmpharmatech.com |
| Products Intro: |
Product Name:TH1020
CAS:1841460-82-9
Purity:>98% Package:1g/;10g/;100g/ Remarks:2g
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:TH 1020
CAS:1841460-82-9
Purity:98% by HPLC Remarks:TH 1020 is a toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). TH 1020 competes with flagellin for TLR5 binding to inhibit the downstream TNF-α signaling pathways.
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| | TH1020 Basic information | | Uses |
| Product Name: | TH1020 | | Synonyms: | TH1020;4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine;4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2';TH1020 >=95% (HPLC);4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine;interaction,inhibit,Bacterial,flagellin,TH-1020,TH1020,Toll-like Receptor (TLR),TLR5,protein-protein,TNF-α,Inhibitor,TH 1020;Pyrido[3',2':4,5]thieno[3,2-d]pyrimidine, 4-[[4-(phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-;4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine | | CAS: | 1841460-82-9 | | MF: | C23H15N7S2 | | MW: | 453.54 | | EINECS: | | | Product Categories: | | | Mol File: | 1841460-82-9.mol |  |
| | TH1020 Chemical Properties |
| Boiling point | 765.8±70.0 °C(Predicted) | | density | 1.51±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Chloroform: 1 mg/ml | | form | powder | | pka | 1.92±0.10(Predicted) | | color | white to beige |
| | TH1020 Usage And Synthesis |
| Uses | TH 1020 is a toll-like receptor 5 (TLR5)/flagellin complex inhibitor. | | Uses | TH1020 has been used to inhibit toll-like receptor 5 (TLR5) in porcine intestinal epithelial monolayer cells and mice. | | Biochem/physiol Actions | TH1020 is a non-cytotoxic non-cytotoxic toll-like receptor 5 (TLR5)/flagellin complex inhibitor. TH1020 selectively prevents flagellin-induced TLR5 signaling without affecting ligands-induced activation of TLR2, TLR3, TLR4, TLR7 or TLR8. | | storage | Store at +4°C |
| | TH1020 Preparation Products And Raw materials |
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