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| | COMPOUND 52 Basic information |
| Product Name: | COMPOUND 52 | | Synonyms: | NG-52;2-(2-HYDROXYETHYLAMINO)-6-(3-CHLORANILINO)-9-ISOPROPYLPURINE;2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE;COMPOUND 52;2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-52;2-((6-((3-chlorophenyl)aMino)-9-isopropyl-9H-purin-2-yl)aMino)ethanol;2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]ethanol;NG 52 (Compound 52 ) | | CAS: | 212779-48-1 | | MF: | C16H19ClN6O | | MW: | 346.81 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | Mol File |  |
| | COMPOUND 52 Chemical Properties |
| Boiling point | 587.7±60.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | methylene chloride: 50 mg/mL, clear, colorless | | form | powder | | pka | 14.54±0.10(Predicted) | | color | white to off-white |
| Hazard Codes | Xn | | Risk Statements | 40-68 | | Safety Statements | 36/37 | | WGK Germany | 3 |
| | COMPOUND 52 Usage And Synthesis |
| Description | NG 52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p (IC50s = 7 and 2 μM, respectively). It is ineffective against the yeast kinases Kin28p, Srb10, and Cak1p. NG 52 is cell permeable and inhibits the growth of S. cerevisiae (GI50 = 30 μM). It is an analog of purvalanol A , a potent inhibitor of mammalian cyclin-dependent kinases. |
| | COMPOUND 52 Preparation Products And Raw materials |
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