| Company Name: |
Hefei Molake Biotechnology Co., Ltd.
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| Tel: |
0551-66336380 18956014586 |
| Email: |
983438788@qq.com |
| Products Intro: |
Product Name:Cetirizine-d8 DiHCl
CAS:2070015-04-0
Purity:98% Package:10mg,100mg,1g,10g
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Cetirizine-d8 hydrochloride
CAS:2070015-04-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Email: |
3003867561@qq.com |
| Products Intro: |
Product Name:Cetirizine D8 dihydrochloride
CAS:2070015-04-0
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
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Cetirizine-d8 (hydrochloride) manufacturers
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| | Cetirizine-d8 (hydrochloride) Basic information |
| | Cetirizine-d8 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Methanol: slightly soluble; Water: slightly soluble | | form | A solid | | Stability: | Hygroscopic |
| | Cetirizine-d8 (hydrochloride) Usage And Synthesis |
| Description | Cetirizine-d8 (hydrochloride) is intended for use as an internal standard for the quantification of cetirizine , (R)-cetirizine , and (S)-cetirizine by GC- or LC-MS. Cetirizine is a bioactive carboxylated metabolite of hydroxyzine that acts as a selective histamine H1 receptor antagonist (Ki = 10 nM). As a second generation antihistamine, it is non-sedating due to low lipophilicity, which prevents blood-brain barrier transit. Cetirizine is a racemic mixture composed of equal amounts of two enantiomers, (R)-cetirizine and (S)-cetirizine, with pharmacological activity residing primarily in the (R) isomer. Cetirizine inhibits eosinophil chemotaxis and leukotriene B4 (LTB4; ) release independent from H1 antagonism. It inhibits aerosol histamine-induced bronchospasm in guinea pigs (ED50 = 100 μg/kg, p.o.). Formulations containing cetirizine have been used in the treatment of allergic rhinitis and chronic urticaria. | | Uses | A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic. |
| | Cetirizine-d8 (hydrochloride) Preparation Products And Raw materials |
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