| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-SIRT7 antibody produced in rabbit
Purity:affinity isolated antibody Package:50UG Remarks:SAB2103966-50UG
|
| Company Name: |
Riedel-de Haen AG
|
| Tel: |
800 558-9160 |
| Email: |
|
| Products Intro: |
Purity:affinity isolated antibody, lyophilized powder Remarks:affinity isolated antibody, buffered aqueous solution
|
|
| | ANTI-HUMAN SIRTUIN TYPE 7 (SIRT 7) Basic information |
| Product Name: | ANTI-HUMAN SIRTUIN TYPE 7 (SIRT 7) | | Synonyms: | Anti-Sirtuin (silent mating type information regulation 2 homolog);Anti-sirtuin 2;Anti-Sirtuin (silent mating type information Regulation 2 homolog) 7 (S. cerevisiae);Anti-sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae);Monoclonal Anti-SIRT2 antibody produced in mouse;Anti-SIRT2 (AB2) antibody produced in rabbit;Anti-MGC126840;Anti-MGC126842 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-HUMAN SIRTUIN TYPE 7 (SIRT 7) Structure]() |
| | ANTI-HUMAN SIRTUIN TYPE 7 (SIRT 7) Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-HUMAN SIRTUIN TYPE 7 (SIRT 7) Usage And Synthesis |
| Uses | Anti-Sirt7 antibody produced in rabbit has been used in western blotting analysis and immunofluorescence detection. | | General Description | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. (provided by RefSeq) | | Biochem/physiol Actions | Sirt7 (sirtuin 7) is extensively found in protein associated with active rRNA genes (rDNA), in the nucleolus. It interacts with RNA polymerase I (Pol I) and histones. Overexpression of Sirt7 increases Pol I-mediated transcription, whereas knockdown of Sirt7 or inhibition of its catalytic activity results in decreased association of Pol I with rDNA and reduces Pol I transcription. Depletion of Sirt7 stops cell proliferation and triggers apoptosis. High levels of Sirt7 expression are associated with breast cancer. |
| | ANTI-HUMAN SIRTUIN TYPE 7 (SIRT 7) Preparation Products And Raw materials |
|