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| Product Name: | BP 897 | | Synonyms: | BP897/BP-897;N-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-2-naphthalenecarboxamide monohydrochloride;N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]naphthalene-2-carboxamide;BP897 >98% (HPLC), solid;N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide hydrochloride;BP 897 (hydrochloride);Inhibitor,inhibit,stimuli,BP-897,behaviour,Dopamine Receptor,BP 897 hydrochloride,addiction,rewarding,BP 897,cocaine drug-seeking,motivational,BP897 | | CAS: | 314776-92-6 | | MF: | C26H31N3O2 | | MW: | 417.55 | | EINECS: | | | Product Categories: | | | Mol File: | 314776-92-6.mol |  |
| | BP 897 Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: 10 mg/mL, soluble | | form | solid | | color | off-white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | BP 897 Usage And Synthesis |
| Description | BP-897 is a dopamine D3 receptor partial agonist. It selectively binds to the dopamine D3 over the D2, D1, and D4 receptors (Kis = 0.92, 61, 3,000, and 300 nM, respectively, for the recombinant human receptors). It is also selective over α1- and α2-adrenergic receptors (Kis = 60 and 83 nM, respectively) and the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT7 (Kis = 84 and 345 nM, respectively), as well as muscarinic, histamine, and opioid receptors (Kis = >1 μM for all). BP-897 inhibits cAMP accumulation induced by forskolin (EC50 = 1 nM) and increases mitogenesis in NG 108-15 cells with a maximum efficacy of 55%, an effect that can be blocked by the dopamine D3 receptor antagonist nafadotride. It also acts as a dopamine D3 receptor antagonist, failing to increase [35S]GTPγS binding to CHO cell membranes expressing the recombinant human D3 receptor and inhibiting the effect of dopamine in the same assay (IC50 = 416.87 nM). BP-897 (0.5 and 1 mg/kg) reduces cocaine-seeking behavior, but has no reinforcing properties itself, in rats trained to self-administer cocaine. | | Biochem/physiol Actions | Partially selective D3 dopamine receptor agonist. |
| | BP 897 Preparation Products And Raw materials |
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