N-丙戊酰基甘氨酰胺
中文名称 | N-丙戊酰基甘氨酰胺 |
---|---|
中文同义词 | N-丙戊酰基甘氨酰胺;丙戊塞胺;N-(2-氨基-2-氧代乙基)-2-丙基戊酰胺 |
英文名称 | VALROCEMIDE |
英文同义词 | VALROCEMIDE;TV 1901;N-(2-Amino-2-oxoethyl)-2-propylpentanamide;N-Valproylglycinamide;Valrocemide (TV1901,VGD));Valrocemide, >98%;Valrocemide(TV1901);Valrocemide,Inhibitor,TV-1901,inhibit,TV 1901 |
CAS号 | 92262-58-3 |
分子式 | C10H20N2O2 |
分子量 | 200.28 |
EINECS号 | |
相关类别 | |
Mol文件 | 92262-58-3.mol |
结构式 |
N-丙戊酰基甘氨酰胺 性质
沸点 | 417.5±28.0 °C(Predicted) |
---|---|
密度 | 0.997 |
储存条件 | Store at -20°C |
溶解度 | DMF:30mg/mL;二甲基亚砜:30mg/mL; DMSO:PBS (pH 7.2) (1:4):0.2mg/mL;乙醇:25mg/mL |
形态 | 固体 |
酸度系数(pKa) | 15.23±0.46(Predicted) |
颜色 | 白色至米白色 |
In mice, valrocemide affords complete protection against maximal electroshock-, pentylenetetrazole-, picrotoxin-, and bicuculline-induced seizures and 6-Hz “psychomotor” seizures with median effective dose (ED 50 ) values of 151, 132, 275, 248, and 237 mg/kg, respectively. Valrocemide is also effective in preventing sound-induced seizures in Frings audiogenic-seizure susceptible mice (ED 50 , 52 mg/kg). The median neurotoxic dose in mice is 332 mg/kg. After oral administration to rats, valrocemide is active in the MES test, with an ED 50 of 73 mg/kg, and the median neurotoxic dose is 1,000 mg/kg. Intraperitoneal administration of 300 mg/kg of valrocemide to hippocampal kindled Sprague–Dawley rats block generalized seizures and shorten the afterdischarge duration significantly. Valrocemide also provides complete protection from focal seizures in the corneally kindled rats (ED 50 , 161 mg/kg).
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-100379 | N-丙戊酰基甘氨酰胺 Valrocemide | 92262-58-3 | 5mg | 850元 |
2024/08/19 | HY-100379 | N-丙戊酰基甘氨酰胺 Valrocemide | 92262-58-3 | 10mM * 1mLin DMSO | 935元 |