| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:LDN-0088050;LDN0088050,LDN 0088050
CAS:353484-30-7
Purity:98% Package:5 mg
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| | LDN-0088050 Basic information |
| Product Name: | LDN-0088050 | | Synonyms: | LDN-0088050;LDN0088050,LDN 0088050;Benzo[ij]dicyclopenta[b,g]quinolizine-7-carboxylic acid, 2-bromo-3b,6,6a,7,9,9a,10,12a-octahydro- | | CAS: | 353484-30-7 | | MF: | C19H18BrNO2 | | MW: | 372.26 | | EINECS: | | | Product Categories: | | | Mol File: | 353484-30-7.mol |  |
| | LDN-0088050 Chemical Properties |
| Boiling point | 494.4±45.0 °C(Predicted) | | density | 1.61±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 6.61±0.20(Predicted) |
| | LDN-0088050 Usage And Synthesis |
| Description | LDN 0088050 is selectivity adipocyte fatty acid binding protein (AFABP, FABP4) inhibitor with Ki values of 0.29 and 1.3 μM for FABP4 and FABP3, respectively. LDN 0088050 binds to FABP4 with a Kd of 2.05 μM[1].
Ki: 0.29 μM (FABP4), 1.3 μM (FABP3)[1]Kd: 2.05 μM (FABP4)[1] LDN 0088050 significantly inhibits LPS-induced expression of both TNFα and IL-6 in RAW264.7 cells[1]. | | References | [1]. Zhou Y, et al. The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation. Bioorg Med Chem. 2016 Sep 15;24(18):4310-4317. |
| | LDN-0088050 Preparation Products And Raw materials |
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