3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)
| 中文名称 | 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) |
|---|---|
| 中文同义词 | |
| 英文名称 | 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) |
| 英文同义词 | 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2);(R)-3-Hydroxy Midostaurin;(R)-CGP52421;Midostaurin Impurity 2;Benzamide, N-[(3R,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-;Midostaurin Impurity 4;P39.8 (CGP52421 Epimer 2) |
| CAS号 | 155848-20-7 |
| 分子式 | C35H30N4O5 |
| 分子量 | 586.65 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 155848-20-7.mol |
| 结构式 |  |
3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) 性质
| 密度 | 1.53±0.1 g/cm3(Predicted) |
|---|---|
| 酸度系数(pKa) | 12.23±0.70(Predicted) |
(R)-3-Hydroxy Midostaurin ((R)-CGP52421) 是有效的激酶抑制剂。(R)-3-Hydroxy Midostaurin 是 Midostaurin (PKC412; HY-10230) 通过肝 CYP3A4 酶代谢的主要代谢产物。(R)-3-Hydroxy Midostaurin 具有潜在的用于急性髓细胞性白血病 (AML) 的潜力。
(R)-3-Hydroxy Midostaurin ((R)-CGP52421; compound 5) has IC
50
values in the range of 200-400 nM against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme.
The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI
50
=63 nM), KIT D816V (GI
50
=320 nM), and FLT3-ITD (GI
50
=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive.