化合物NAE-IN-M22
中文名称 | 化合物NAE-IN-M22 |
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中文同义词 | 化合物NAE-IN-M22;NEDD8抑制剂M22 |
英文名称 | NEDD8 inhibitor M22 |
英文同义词 | NEDD8 inhibitor M22;4-Piperidinamine, N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-;NAE-IN-M22;NAEINM22,cancer,Inhibitor,NAE-IN-M-22,NAE,NEDD8,NAE IN M22,enzyme,activating,inhibit,tumor,Apoptosis |
CAS号 | 864420-54-2 |
分子式 | C20H24Cl2N2 |
分子量 | 363.32 |
EINECS号 | |
相关类别 | |
Mol文件 | 864420-54-2.mol |
结构式 | ![]() |
化合物NAE-IN-M22 性质
储存条件 | Store at -20°C |
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溶解度 | 二甲基亚砜:250 mg/mL(688.10 mM) |
形态 | 固体 |
颜色 | 白色至米白色 |
NEDD8 activating enzyme (NAE)
M22 (0.37-90 μM; 24 h) blocks neddylation pathway selectively and suppresses degradation of CRL substrates in A549 cells.
M22 (0.1-100 μM; 48 h) inhibits A549 cell proliferation completely at 30 µM (GI
50
=5.5 µM, GI
90
=19.3 µM).
M22 (15-30 μM; 36 h) promotes apoptosis in A549 cell line.
Cell Viability Assay
Cell Line: | A549 cells |
Concentration: | 0.37, 1.11, 3.33, 10, 30, 90 μM |
Incubation Time: | 24 hours |
Result: |
Inhibited formations of Uba3-NEDD8 and Ubc12-NEDD8.
Resulted in a corresponding decrease in the abundance of Cullins-NEDD8. Decreased the degradations of p27 and CDT1. Prevented p53 from degradation. |
M22 (60 mg/kg; i.p. once daily for 14 d) inhibits tumor growth in nude mice bearing AGS xenografts.
M22 (0.36-90 μM) has low acute toxicity in zebrafish model.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-115537 | NAE-IN-M22 | 1 mg | 960元 | |
2024/08/19 | HY-115537 | 化合物NAE-IN-M22 NAE-IN-M22 | 864420-54-2 | 5mg | 2400元 |