| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Docosanoic Acid-d4
CAS:1208430-53-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Reer Technology (Shanghai) Co., LTD
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| Tel: |
021-64400900 15800436310 |
| Email: |
bessey@reertech.com |
| Products Intro: |
Product Name:DOCOSANOIC ACID(3,3,5,5-D4, 98%) CHEMICAL PURITY 95%
CAS:1208430-53-8
Purity:95% Package:G Remarks:DLM-9951-PK
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| | Docosanoic Acid-d4 Basic information |
| | Docosanoic Acid-d4 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 3 mg/ml,DMF:PBS (pH 7.2): 0.5 mg/ml |
| | Docosanoic Acid-d4 Usage And Synthesis |
| Biological Activity | Docosanoic acid-d4 is intended for use as an internal standard for the quantification of docosanoic acid by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.1,2 It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).3 Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase Λ activity in cell-free enzyme assays when used at a concentration of 100 μM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 μM.4 Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.5 Formulations containing docosanoic acid have been used in hair conditioner and moisturizers. | | References | 1.Dean, L.L., and Sanders, T.H.Hexacosanoic acid and other very long-chain fatty acids in peanut seed oilPlant Genet. Resour.7(3)252-256(2009)
2.Sánchez-Machado, D.I., López-Cervantes, J., Nú?ez-Gastélum, J.A., et al.Effect of the refining process on Moringa oleifera seed oil qualityFood Chem.18753-57(2015)
3.Iijima, H., Kasai, N., Chiku, H., et al.The inhibitory action of long-chain fatty acids on the DNA binding activity of p53Lipids41(6)521-527(2006)
4.Yonezawa, Y., Hada, T., Uryu, K., et al.Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerasesInt. J. Mol. Med.18(4)583-588(2006)
5.Serviddio, G., Bellanti, F., Villani, R., et al.Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approachRedox Biol.9296-305(2016) |
| | Docosanoic Acid-d4 Preparation Products And Raw materials |
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