Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Tel: |
18818260767 |
Email: |
sales@chemegen.com |
Products Intro: |
Product Name:GKK1032B CAS:358375-11-8 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Company Name: |
Nanjing Tengyi Biotechnology Co., Ltd
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Tel: |
025-58851786 17714337195 |
Email: |
sales@tybiochem.com |
Products Intro: |
Product Name:(3aR,9aR,9bS,10R,12S,13aR,13bR,13cR,16R,16aS,17aS)-rel-(+)-16-ethenyl-3a,9b,10,11,12,13,13a,13b,13c,16,16a,17a-dodecahydro-10,12,13a,14,16-pentamethyl-5,8-ethenofluoreno[9',1':2,3,4]oxacyclododecino[6,7-c]pyrrole-1,3,17(2H,4H,9aH)-trione CAS:358375-11-8 Purity:95+% Package:1g;5g
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| GKK1032B Basic information |
Product Name: | GKK1032B | Synonyms: | GKK1032B;5,8-Ethenofluoreno[9',1':2,3,4]oxacyclododecino[6,7-c]pyrrole-1,3,17(2H,4H,9aH)-trione, 16-ethenyl-3a,9b,10,11,12,13,13a,13b,13c,16,16a,17a-dodecahydro-10,12,13a,14,16-pentamethyl-, (3aR,9aR,9bS,10R,12S,13aR,13bR,13cR,16R,16aS,17aS)-rel-(+)-;(3aR,9aR,9bS,10R,12S,13aR,13bR,13cR,16R,16aS,17aS)-rel-(+)-16-ethenyl-3a,9b,10,11,12,13,13a,13b,13c,16,16a,17a-dodecahydro-10,12,13a,14,16-pentamethyl-5,8-ethenofluoreno[9',1':2,3,4]oxacyclododecino[6,7-c]pyrrole-1,3,17(2H,4H,9aH)-trione | CAS: | 358375-11-8 | MF: | C32H39NO4 | MW: | 501.66 | EINECS: | | Product Categories: | | Mol File: | Mol File | ![GKK1032B Structure]() |
| GKK1032B Chemical Properties |
Boiling point | 653.9±55.0 °C(Predicted) | density | 1.130±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | Dichloromethane: soluble; DMSO: soluble; Ethanol: soluble | form | A solid | pka | 8.99±0.70(Predicted) |
| GKK1032B Usage And Synthesis |
Description | GKK1032B is a fungal metabolite that has antiproliferative and antibacterial activities. GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells and Vero cells. It also inhibits the growth of B. subtilis and M. tuberculosis. | in vitro | Among them, GKK1032B showed significant cytotoxicity against human osteosarcoma cell line MG63 with an IC50 value of 3.49 μmol·L-1, and a primary mechanistic study revealed that it induced the apoptosis of MG63 cellsvia caspase pathway activation._x000D_
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Reference: Chin J Nat Med. 2022 Jan;20(1):67-73. https://pubmed.ncbi.nlm.nih.gov/35101251/ | target | GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation. |
| GKK1032B Preparation Products And Raw materials |
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