SHU-9119
| 中文名称 | SHU-9119 |
|---|---|
| 中文同义词 | AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2(CHEMICAL BRIDGE ASP2-LYS7);SHU-9119;CHEMBL3422426;拮抗剂多肽SHU 9119;(3R,6R,9S,12R,15R,23R)-12-((1H-咪唑-5-基)甲基)-3-((1H-吲哚-3-基)甲基)-15-((R)-2-乙酰氨基己酰氨基)-6-(3-胍基丙基)-9-(萘-2-基甲基)-2,5,8,11,14,17-六氧代-1,4,7,10,13,18-六氮杂环二十三烷-23-甲酰胺;化合物 SHU 9119 |
| 英文名称 | SHU-9119 |
| 英文同义词 | SHU-9119;[N-ACETYL-NLE4,ASP5,D-2'-NAL7,LYS10]-ALPHA-MSH (4-10) AMIDE, ASP5-LYS10, CYCLIC LACTAM;AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2;AC-NLE-ASP-HIS-D-2'-NAL-ARG-TRP-LYS-NH2, ASP5-LYS10, CYCLIC LACTAM;AC-NLE-ASP-HIS-D-2-NAL-H2N-LYS-TRP-ARG;AC-NLE-ASP-HIS-D-NAL(2)-ARG-TRP-LYS-NH2;(AC-NLE4,ASP5,D-2-NAL7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE;AC-[NLE4, ASP5, D-2-NAL7, LYS10]-CYCLO-ALPHA-MSH AMIDE (4-10) |
| CAS号 | 168482-23-3 |
| 分子式 | C54H71N15O9 |
| 分子量 | 1074.24 |
| EINECS号 | |
| 相关类别 | 标准品 |
| Mol文件 | 168482-23-3.mol |
| 结构式 |  |
SHU-9119 性质
| 密度 | 1.43±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | H2O：20 mg/mL（18.62 mM；需要超声波） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 13.00±0.70(Predicted) |
| 颜色 | 白色至米白色 |
| 水溶解性 | Soluble to 0.20 mg/ml in water |
| 序列 | Ac-Nle-Asp-His-D-Nal-Arg-Trp-Lys-NH2(Chemical Bridge Asp2-Lys7) |
IC50: 0.23 nM (MC3R); 0.23 nM (MC4R); 0.23 nM (MC5R)
Blockade of CNS-Mcr via chronic intracerebroventricular infusion of SHU9119 (24 nmol/d for 7 days) increases food intake in ad libitum-fed rats compared with control. Weight gain of SHU9119 treated rats is significantly higher than control. SHU9119 treatment potently increases metabolic efficiency. SHU9119 markedly increases mRNA levels of genes promoting lipogenesis and TAG storage in adipocytes, including stearoyl-CoA desaturase-1, lipoprotein lipase, acetyl-CoA carboxylase α, and fatty acid synthase. SHU9119 increases food intake (+30%) and body fat (+50%) and decreases EE by reduction in fat oxidation (−42%). In addition, SHU9119 impairs the uptake of VLDL-TG by BAT. In line with this, SHU9119 decreases uncoupling protein-1 levels in BAT (−60%) and induces large intracellular lipid droplets, indicative of severely disturbed BAT activity.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-P0227 | SHU-9119 SHU 9119 | 168482-23-3 | 1mg | 1100元 |
| 2024/11/08 | HY-P0227 | SHU-9119 SHU 9119 | 168482-23-3 | 5mg | 4400元 |