蝴蝶霉素
中文名称 | 蝴蝶霉素 |
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中文同义词 | 蝴蝶霉素;瑞贝卡霉素;瑞贝卡霉素杂质;瑞贝霉素;化合物 T16726;化合物 REBECCAMYCIN;雷贝卡霉素;REBECCAMYCIN,ANTIBIOTIC AGENT |
英文名称 | REBECCAMYCIN |
英文同义词 | 5h-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6h)-dione,1,11-dichloro-12,13-dihy;dro-12-(4-o-methyl-beta-d-glucopyranosyl)-;REBECCAMYCIN;REBECCAMYCIN, SACCHAROTHRIX AEROCOLONIGENES;1,11-Dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione;NSC 359079;7,10-Dichloro-8-(3,4-dihydroxy-6-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-2-yl)-8,9-dihydro-1H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione;5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)- |
CAS号 | 93908-02-2 |
分子式 | C27H21Cl2N3O7 |
分子量 | 570.38 |
EINECS号 | |
相关类别 | 微生物代谢物 |
Mol文件 | 93908-02-2.mol |
结构式 | ![]() |
蝴蝶霉素 性质
储存条件 | −20°C |
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溶解度 | 二甲基亚砜:≥3 mg/mL |
形态 | 固体 |
颜色 | 粘黄色 |
Topoisomerase I
|
Traditional Cytotoxic Agents
|
Rebeccamycin is an antitumor antibiotic produced by the actinomycete
Saccharotrix aerocolonigenes
with activity against several human tumor cell lines, including A549 (lung adenocarcinoma), HCT-116 (colon carcinoma), and KB (nasopharyngeal carcinoma) .
Rebeccamycin shows antibacterial activity against several Gram-positive bacteria, including
Staphylococcus aureus
and
Streptococcus faecalis
.
Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma, L1210 leukemia.
Animal Model: | CDF1 mice (B16 melanoma, L1210 leukemia) |
Dosage: | 2, 4, 8, 16, 32, 64, 128, 256 mg/kg |
Administration: | I.p.; daily for 9 days |
Result: | Prolongation of survival of the mice at dose levels ranging from 8 to 256 mg/kg. |
安全信息
WGK Germany | - |
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提供商 | 语言 |
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英文
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