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| C-JUN N-TERMINAL KINASE Basic information |
Product Name: | C-JUN N-TERMINAL KINASE | Synonyms: | JNK3;C-JUN N-TERMINAL KINASE;SAPK1B/JNK3;c-Jun N-Terminal Kinase from rat muscle;JNK3, Stress-Activated Protein Kinase;Stress-Activated Protein Kinase;ANTI-MAPK10 antibody produced in mouse;FLJ12099 | CAS: | | MF: | | MW: | 0 | EINECS: | | Product Categories: | | Mol File: | Mol File | ![C-JUN N-TERMINAL KINASE Structure]() |
| C-JUN N-TERMINAL KINASE Chemical Properties |
storage temp. | −70°C | form | buffered aqueous glycerol solution |
| C-JUN N-TERMINAL KINASE Usage And Synthesis |
Uses | JNK-3 is an inhibitor of JNK kinase which may be used in the treatment of many hyperactive JNK signaling diseases such as cancer, inflammatory diseases and neurodegenerative diseases. | General Description | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq) |
| C-JUN N-TERMINAL KINASE Preparation Products And Raw materials |
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