| Company Name: |
Aktin Chemicals, Inc.
|
| Tel: |
86-28-85159085 |
| Email: |
info@aktinchem.com |
| Products Intro: |
Product Name:Songorine
Purity:98% HPLC Package:20Mg, 500Mg, 1g, 5g, 10g
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:Songorine
|
| Company Name: |
Neobioscience Co., Ltd.
|
| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:Songorine
|
| Company Name: |
United States Biological
|
| Tel: |
800.520.3011 or 781.639.5092 |
| Email: |
chemicals@usbio.net |
| Products Intro: |
Product Name:Songorine
|
|
| | SONGORINE Basic information |
| Product Name: | SONGORINE | | Synonyms: | SONGORINE | | CAS: | | | MF: | C22H31NO3 | | MW: | 357.49 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | SONGORINE Chemical Properties |
| Melting point | 212°C (20l-3°C) |
| | SONGORINE Usage And Synthesis |
| Description | Both Aconitum karakoZicum and A. soongoricum contain this atisine type
alkaloid which is strongly laevorotatory with [α]D - 139.89°. The ultraviolet
spectrum contains a single absorption maximum at 290 mil. Several crystalline
salts and derivatives are known including the hydrochloride, m.p. 257-8°C;
[α]D - 113.99° (H20); hydrobromide, m.p. 261°C; nitrate, m.p. 230-l oC
(dec.); perchlorate, m.p. 234-5°C (dec.); methiodide, m.p. 2l3-4°C (dec.) and
the semicarbazone, m.p. 247-8°C (dec.). Catalytic hydrogenation over Pt02
gives the dihydro derivative, m.p. 205-6°C, giving a hydrochloride, m.p. 286-
7°C and a methiodide, m.p. 255-6°C. With AcCl the alkaloid yields the diacetyl
derivative, m.p. l80-2°C, forming a hydrochloride dihydrate, m.p. 239-240°C.
When boiled with KOH for 2 hours, the base gives des-N-methylsongorine,
isolated as the hydrochloride, m.p. 285°C. | | Biological Activity | Aconitum is a genus rich of diverse alkaloids. More than 450 alkaloids have been identified in a variety of species. Songorine is a C20 diterpenoid alkaloid and 12-keto analog of napelline, isolated from Aconitum soongaricum and was associated with a heterogeneous panel of biological functions.
Alkaloids are well-studied secondary metabolites, with recent preclinical studies evidencing that many of them exhibit anti-cancer, anti-depressant, anti-nociceptive, anti-inflammatory, anti-pyretic, anti-platelet, anti-oxidant, and anti-bacterial properties. | | References | Yunusov.,J. Gen. Chem., USSR, 18, 515 (1948)
Wiesner et al., Chem. Ind., 173 (1957)
Yunusovetal., Khim. Prir. Soedin., 6, 101 (1970)
Structure:
Wiesner, Ito, Valenta., Experientia, 14,167 (1958)
Sugasawa., Chem. Pharm. Bull. (Tokyo), 9, 897 (1961)
Absolute configuration:
Okamoto et al., Chem. Pharm. Bull. (Tokyo), 13, 1270 (1965) |
| | SONGORINE Preparation Products And Raw materials |
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