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Product Name:NCGC00092410
CAS:442898-34-2
Purity:98% HPLC Package:100mg，250mg，1g
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| | NCGC00092410 Basic information |
| Product Name: | NCGC00092410 | | Synonyms: | NCGC00092410;ML008;Cyclohexanecarboxamide, N-[4-methyl-2-(4-morpholinyl)-6-quinolinyl]- | | CAS: | 442898-34-2 | | MF: | C21H27N3O2 | | MW: | 353.46 | | EINECS: | | | Product Categories: | | | Mol File: | 442898-34-2.mol |  |
| | NCGC00092410 Chemical Properties |
| Boiling point | 627.9±55.0 °C(Predicted) | | density | 1.210±0.06 g/cm3(Predicted) | | solubility | DMSO : 41.67 mg/mL (117.89 mM; Need ultrasonic) | | pka | 14.93±0.20(Predicted) |
| | NCGC00092410 Usage And Synthesis |
| Definition | ChEBI: N-[4-methyl-2-(4-morpholinyl)-6-quinolinyl]cyclohexanecarboxamide is an aminoquinoline. | | Biological Activity | NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410 shows no activity against the related hydrolases at concentrations up to 77 μM. NCGC00092410, a GC chaperone, and increases the activity and lysosomal localization of glucocerebrosidase in mutant cell lines. NCGC00092410 can be used for the research of Gaucher disease[1].
NCGC00092410 (7.3-130 nM; 25 min) inhibits the GC activity at various substrate concentrations (10-150 μM) in a dose-dependent manner[1].NCGC00092410 (55-40 μM; 2 d) increases the GC activity in the N370S mutant fibroblasts[1].NCGC00092410 (40 μM; 60-72 h) increases the lysosomal localization of GC in gaucher fibroblasts[1]. | | References | [1]. Zheng W, et, al. Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7. |
| | NCGC00092410 Preparation Products And Raw materials |
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