5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro- manufacturers
- JHU37160
-
- $42.00 / 10mg
-
2024-11-19
- CAS:2369979-68-8
- Min. Order:
- Purity: 99.25%
- Supply Ability: 10g
|
| | 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro- Basic information |
| Product Name: | 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro- | | Synonyms: | 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro-;8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro-5H-Dibenzo[b,e][1,4]diazepine;Inhibitor,hM4Di,Clozapine,hM3Dq,DREADD,inhibit,Muscarinic acetylcholine receptor,JHU-37160,JHU37160,mAChR;JHU37160, 10 mM in DMSO | | CAS: | 2369979-68-8 | | MF: | C19H20ClFN4 | | MW: | 358.84 | | EINECS: | | | Product Categories: | | | Mol File: | 2369979-68-8.mol | ![5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro- Structure](CAS/20210111/GIF/2369979-68-8.gif) |
| | 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro- Chemical Properties |
| Boiling point | 493.0±55.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | DMSO|17.94|50| | | pka | 7.63±0.10(Predicted) | | form | solid | | color | Yellow |
| | 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro- Usage And Synthesis |
| Biological Activity | JHU37160 (J60) is a potent DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) ligand (hM3Dq/hM4Di Ki = 1.9/3.6 nM using mouse brain tissue, 18.5/0.2 nM by celluar BRET assays) with ~25-fold improved affinity than C21 and high in vivo potency for CNS applications. J60 selectively competes against clozapine at DREADDs, but not other clozapine-binding sites in mouse brain tissue ex vivo (10 nM), increases hM3Dq-stimulated locomotion in TH-hM3Dq rats (0.01-0.3 mg/kg i.p.) and selectively inhibits locomotor activity of D1-hM3Dq and D1-hM4Di transgenic, but not wild-type, mice (0.01-1 mg/kg i.p.). | | storage | Room temperature |
| | 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro- Preparation Products And Raw materials |
|