| Company Name: |
Shanghai Chaolan Chemical Technology Center
|
| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:Ro0711401
CAS:714971-87-6
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| Company Name: |
Shanghai Dongyang Biotechnology Co., Ltd.
|
| Tel: |
0512-0512-13601744364 13601744364 |
| Email: |
chemsharker@126.com |
| Products Intro: |
Product Name:Ro0711401
CAS:714971-87-6
Purity:98% Package:1g 5g 10g 25g 50g 100g
|
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| | 9H-Xanthene-9-carboxamide, N-[4-(trifluoromethyl)-2-oxazolyl]- Basic information |
| | 9H-Xanthene-9-carboxamide, N-[4-(trifluoromethyl)-2-oxazolyl]- Chemical Properties |
| density | 1.469±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (277.55 mM; Need ultrasonic) | | form | Solid | | pka | 11.52±0.20(Predicted) | | color | White to off-white |
| | 9H-Xanthene-9-carboxamide, N-[4-(trifluoromethyl)-2-oxazolyl]- Usage And Synthesis |
| Biological Activity | RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM[1][2].
RO0711401 (10 mg/kg; s.c.; once) causes a long-lasting improvement in motor performance, which is maintained to the same extent at least for 6 days[1].Systemic injection of RO0711401 is shown to reduce the frequency of spike-and-wave discharges in a rat model of absence epilepsy, and to improve motor signs in autoimmune encephalomyelitis (EAE) mice[1]. | | References | [1]. Serena Notartomaso, et al. Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1. Mol Brain. 2013 Nov 19;6:48. [2]. Eric Vieira, et al. Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1666-9. |
| | 9H-Xanthene-9-carboxamide, N-[4-(trifluoromethyl)-2-oxazolyl]- Preparation Products And Raw materials |
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