| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:mTOR inhibitor-8
CAS:2489196-70-3
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:mTOR inhibitor-8；mTOR-IN-8
CAS:2489196-70-3
Purity:98.11% Package:详见官网
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| | Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Basic information |
| | Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Chemical Properties |
| Boiling point | 626.0±65.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 25 mg/mL (55.93 mM; Need ultrasonic) | | pka | 3.00±0.10(Predicted) | | form | Solid | | color | White to yellow |
| | Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Usage And Synthesis |
| Biological Activity | mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells[1].
mTOR inhibitor-8 (Compound 5e; 0.1-10 μM; 24 and 48 hours) suppresses the growth of A549 cells in a dose-dependent manner[1].mTOR inhibitor-8 induces autophagy in an mTOR-dependent manner. mTOR inhibitor-8 (10 μM; 3-24 hours) induces autophagy in a time-dependent manner. The levels of LC3B-II are enhanced[1].mTOR inhibitor-8 (10 μM; 3-24 hours) reduces the phosphorylation of RPS6KB1 (ribosomal protein S6 kinase) and EIF4EBP1 (eukaryotic translation initiation factor 4E-binding protein 1), two essential substrates of mTOR[1]
mTOR inhibitor-8 (25 and 50 μM; 6 days) effectively inhibits tumor growth in vivo without adverse effect on normal chick chorioallantoic membrane angiogenesis[1]. | | References | [1]. ZhaoMin Lin, et al. Discovery of new fluorescent thiazole-pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells. Cell Death Dis. 2020 Jul 20;11(7):551. |
| | Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Preparation Products And Raw materials |
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