Company Name: |
TargetMol Chemicals Inc.
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Tel: |
15002134094 |
Email: |
marketing@targetmol.cn |
Products Intro: |
Product Name:Cmpd-A CAS:1446399-26-3 Package:50mg/RMB 19800;100mg/RMB 25500;25mg/RMB 15000
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| Imidazo[1,2-a]pyridine-2-carboxamide, N-[7-cyano-2,3-dihydro-1,1-dioxido-6-(trifluoromethyl)benzo[b]thien-3-yl]-N-[2-(dimethylamino)ethyl]-3-(4-fluoro-3-methylphenyl)-5-methoxy- Basic information |
| Imidazo[1,2-a]pyridine-2-carboxamide, N-[7-cyano-2,3-dihydro-1,1-dioxido-6-(trifluoromethyl)benzo[b]thien-3-yl]-N-[2-(dimethylamino)ethyl]-3-(4-fluoro-3-methylphenyl)-5-methoxy- Chemical Properties |
density | 1.42±0.1 g/cm3(Predicted) | pka | 8.13±0.28(Predicted) |
| Imidazo[1,2-a]pyridine-2-carboxamide, N-[7-cyano-2,3-dihydro-1,1-dioxido-6-(trifluoromethyl)benzo[b]thien-3-yl]-N-[2-(dimethylamino)ethyl]-3-(4-fluoro-3-methylphenyl)-5-methoxy- Usage And Synthesis |
Description | Cmpd-A is a time-dependent CENP-E inhibitor with potent antitumor activity. Cmpd-A inhibits the ATPase activity of the CENP-E motor domain, acting as a time-dependent inhibitor with an ATP-competitive-like behavior. Cmpd-A causes chromosome misalignment on the metaphase plate, leading to prolonged mitotic arrest. Treatment with Cmpd-A induces antiproliferation in multiple cancer cell lines. |
| Imidazo[1,2-a]pyridine-2-carboxamide, N-[7-cyano-2,3-dihydro-1,1-dioxido-6-(trifluoromethyl)benzo[b]thien-3-yl]-N-[2-(dimethylamino)ethyl]-3-(4-fluoro-3-methylphenyl)-5-methoxy- Preparation Products And Raw materials |
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