SR 11302
| 中文名称 | SR 11302 |
|---|---|
| 中文同义词 | 化合物SR 11302 |
| 英文名称 | SR 11302 |
| 英文同义词 | SR 11302;(E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoicacid;RQANARBNMTXCDM-DKOHIBGUSA-N;2,4,6,8-Nonatetraenoic acid, 3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (2E,4E,6Z,8E)-;(2E,4E,6Z,8E)-3-Methyl-7-(p-tolyl)-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid;acid,SR11302,retinoid,SR-11302,Lung,RARE,Cancer,response,Inhibitor,protein-1,SR 11302,inhibit,AP-1,retinoic,element,activator |
| CAS号 | 160162-42-5 |
| 分子式 | C26H32O2 |
| 分子量 | 376.53 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 160162-42-5.mol |
| 结构式 |  |
SR 11302 性质
| 沸点 | 541.6±30.0 °C(Predicted) |
|---|---|
| 密度 | 1.048±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 4.67±0.33(Predicted) |
| 颜色 | 浅黄至黄色 |
AP-1
SR 11302 (SR11302) show strong anti-AP-1 activity with selective binding with RARα and RARγ, but not with RARβ and RXRα.
SR 11302 (SR-11302; 1 μM) inhibits AP-1 transcription factor activity and decreases aldosterone levels by 61.9% in hypoxia-treated cells.
SR 11302 (SR-11302; 2 µM; 48 hours) inhibits
Helicobacter pylori
(
H. pylori
)-induced cell proliferation in adenocarcinoma gastric (AGS) cells.
SR 11302 (2 µM; 24 hours) inhibits
H. pylori
-induced expression of β-catenin and c-myc in AGS cells.
SR 11302 (SR11302; low dose 0.5 mg/kg and high dose 1 mg/kg body weight; orally gavaged daily) treatment reduces the total vascular lesion number and lesion size in Vldlr -/- mice in a dose-dependent manner.
| Animal Model: | Vldlr -/- mice |
| Dosage: | Low dose 0.5 mg/kg and high dose 1 mg/kg body weight |
| Administration: | Orally gavaged daily from P5 to P15 |
| Result: | High-dose from P5 to P15 reduced the total vascular lesion number by 48% and decreased the lesion size by 40%, without detectable signs of toxicity in mice, including no change in body weight. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-15870 | SR 11302 | 1 mg | 609元 | |
| 2024/04/30 | HY-15870 | SR 11302 SR 11302 | 160162-42-5 | 5mg | 1600元 |