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| 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Basic information |
Product Name: | 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE | Synonyms: | 5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one;HYDROXYFASUDIL;HA-1100;HA 1100;HA1100;1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE;1H-1,4-Diazepine, hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-;Ha 1100;Hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-1H-1,4-diazepine;1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepinehydrochloride;HA 1100 HYDROCHLORIDE | CAS: | 105628-72-6 | MF: | C14H17N3O3S | MW: | 307.37 | EINECS: | | Product Categories: | Angiogenesis and Metastasis;Intracellular signaling | Mol File: | 105628-72-6.mol | |
| 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Chemical Properties |
storage temp. | Sealed in dry,Store in freezer, under -20°C | solubility | Soluble in DMSO | form | Solid | color | White to off-white |
Toxicity | mouse,LD50,unreported,145mg/kg (145mg/kg),United States Patent Document. Vol. #4678783, |
| 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Usage And Synthesis |
Biological Activity | Cell-permeable active metabolite of Fasudil (HA 1077; Fasudil hydrochloride). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo . |
| 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Preparation Products And Raw materials |
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