Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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Tel: |
15076683720 |
Email: |
klq@cw-bio.com |
Products Intro: |
Product Name:EAAT2 activator 1 CAS:892415-28-0 Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- manufacturers
- EAAT2 activator 1
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- $33.00 / 5mg
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2024-10-30
- CAS:892415-28-0
- Min. Order:
- Purity: 98.86%
- Supply Ability: 10g
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| Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Basic information |
Product Name: | Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- | Synonyms: | Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)-;EAAT2 activator 1;3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine;F2005-0304;GLT-1,Excitatory amino acid transporter 2,inhibit,Glutamate transporter 1,Inhibitor,EAAT-2 activator 1,EAAT2 activator 1,EAAT2,glutamate transporter,synapse;ω- transaminase | CAS: | 892415-28-0 | MF: | C16H11ClFN3S | MW: | 331.8 | EINECS: | | Product Categories: | | Mol File: | 892415-28-0.mol | |
| Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Chemical Properties |
Boiling point | 527.6±50.0 °C(Predicted) | density | 1.41±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO : 25 mg/mL (75.35 mM; ultrasonic and warming and heat to 60°C) | pka | 0.65±0.19(Predicted) | form | Solid | color | Light brown to brown |
| Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Usage And Synthesis |
Biological Activity | EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently[1]. | References | [1]. Xing X, et al. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011;21(19):5774-5777. |
| Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Preparation Products And Raw materials |
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