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Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-

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Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Suppliers list
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
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Products Intro: Product Name:LEI110
CAS:2313525-90-3
Purity:0.98 Package:5mg，10mg，100mg，500mg，1g，5g，10g，more
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:LEI110
CAS:2313525-90-3
Package:1 mg；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
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Products Intro: Product Name:LEI110
CAS:2313525-90-3
Purity:98% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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Products Intro: Product Name:LEI110
CAS:2313525-90-3
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Products Intro: Product Name:LEI110
CAS:2313525-90-3
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Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Basic information
Product Name:Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-
Synonyms:Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-;HepG2 cells,inhibit,thiol hydrolases,LEI110,Inhibitor,LEI-110,lipolysis,Phospholipase,LEI 110
CAS:2313525-90-3
MF:C25H23F3N2O3
MW:456.47
EINECS:
Product Categories:
Mol File:2313525-90-3.mol
Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Structure
Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Chemical Properties
density 1.247±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Ethanol: soluble
form A solid
pka12.15±0.46(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Usage And Synthesis
Biological ActivityLEI-110 is an inhibitor of adipose phospholipase A2 (AdPLA2; IC50 = 100 nM).1 It also inhibits HRas-like suppressor 2 (HRASL2), retinoid acid receptor responder protein 3 (RARRES3), and calcium-independent N-acyltransferase (iNAT; IC50s = 158, 158, and 25 nM, respectively). LEI-110 (10 μM) decreases arachidonic acid levels in U2OS cells expressing human AdPLA2 and prevents oleic acid-induced increases in lipid droplet formation in HepG2 cells.
References1.Zhou, J., Mock, E.D., Martella, A., et al.Activity-based protein profiling identifies α-ketoamides as inhibitors for phospholipase A2 group XVIACS Chem. Biol.14(2)164-169(2019)
Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Preparation Products And Raw materials
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