| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:PW0787
CAS:2624131-45-7
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| Company Name: |
Shanghai Dongyang Biotechnology Co., Ltd.
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| Tel: |
0512-0512-13601744364 13601744364 |
| Email: |
chemsharker@126.com |
| Products Intro: |
Product Name:PW0787
CAS:2624131-45-7
Purity:98% Package:1g 5g 10g 25g 50g 100g
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| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 15221909166 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:1-(6-(3-Fluoro-5-(trifluoromethyl)benzyl)pyrimidin-4-yl)-N-(2-hydroxyethyl)indoline-4-carboxamide
CAS:2624131-45-7
Purity:98+% Package:25mg;50mg;100mg Remarks:BD01465654
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| | INDEX NAME NOT YET ASSIGNED Basic information |
| Product Name: | INDEX NAME NOT YET ASSIGNED | | Synonyms: | PW0787;GPR52,PW-0787,oral,PW0787,Inhibitor,PW 0787,brain-penetrant,selective,inhibit,psychostimulant,behavior | | CAS: | 2624131-45-7 | | MF: | C23H20F4N4O2 | | MW: | 460.43 | | EINECS: | | | Product Categories: | | | Mol File: | 2624131-45-7.mol |  |
| | INDEX NAME NOT YET ASSIGNED Chemical Properties |
| Boiling point | 605.1±55.0 °C(Predicted) | | density | 1.388±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 50 mg/mL (108.60 mM; Need ultrasonic) | | form | Solid | | pka | 14.18±0.20(Predicted) | | color | Off-white to yellow |
| | INDEX NAME NOT YET ASSIGNED Usage And Synthesis |
| Biological Activity | PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM). PW0787 suppresses psychostimulant behavior[1].
PW0787 (0.3, 1, 3, or 10 mg/kg; IP) displays antipsychotic-like activity by significantly inhibiting amphetamine-induced hyperlocomotor behavior in mice[1].PW0787 is evaluated in rats after a single dose of 20 mg/kg by oral (PO) or 10 mg/kg by intravenous (IV) administration. PW0787 has excellent plasma exposure after PO (AUC0-inf = 13,749 ng?h/mL) and IV dosing (AUC0-inf=9030 ng?h/mL), as well as high maximum serum concentration following PO (Cmax=3407 ng/mL) and IV administration (Cmax=6726 ng/mL). Additionally, PW0787 displays good volume of plasma distribution (Vss=1.5 L/kg) and acceptable plasma clearance (CL=1.1 L/h/kg) after 10 mg/kg IV. Excellent oral bioavailability (F) with the value of 76% is observed[1]. | | References | [1]. Wang P, et al. Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior. J Med Chem. 2020;63(22):13951-13972. |
| | INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials |
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