马来酸甲硫替平
| 中文名称 | 马来酸甲硫替平 |
|---|---|
| 中文同义词 | 马来酸甲硫替平;甲磺酸甲替平;1-甲基-4-(8-(甲硫基)-10,11-二氢二苯并[B,F]THIEPIN-10-基)哌嗪甲磺酸盐 |
| 英文名称 | METHIOTHEPIN MESYLATE SEROTININ 5-HT(1) ANT |
| 英文同义词 | METHIOTHEPIN MESYLATE SEROTININ 5-HT(1) ANT;1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt;methiothepin mesylate salt;Metitepine mesylate salt, 1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt;Metitepine mesylate salt;Ro 8-6837 mesylate;Methiothepin mesylate 1-Methyl-4-(3-methylsulfanyl-5,6- dihydrobenzo[b][1]benzothiepin-5-yl)piperazine;1-Methyl-4-(8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl)piperazine methanesulfonate |
| CAS号 | 74611-28-2 |
| 分子式 | C20H24N2S2CH3SO3H |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;Inhibitors |
| Mol文件 | 74611-28-2.mol |
| 结构式 |  |
马来酸甲硫替平 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 在水中的溶解度为13mg/mL |
| 形态 | 固体 |
| 颜色 | 白色 |
|
5-HT 1A Receptor 7.10 (pKd) |
5-HT 1B Receptor 7.28 (pKd) |
5-HT 1C Receptor 7.56 (pKd) |
5-HT 1D Receptor 6.99 (pKd) |
5-HT 5A Receptor 7.0 (pKd) |
5-HT 5B Receptor 7.8 (pKd) |
5-HT 6 Receptor 8.74 (pKd) |
5-HT 7 Receptor 8.99 (pKd) |
5-HT 2A Receptor 8.50 (pKi) |
5-HT 2B Receptor 8.68 (pKi) |
5-HT 2C Receptor 8.35 (pKi) |
Methiothepin mesylate is a 5-HT receptor antagonist, with pK d s of 7.10, 7.28, 7.56, and 6.99 for 5-HT 1A , 5HT 1B , 5HT 1C , 5HT 1D . Methiothepin mesylate also shows pK d s of 7.0, 7.8, 8.74, and 8.99 for 5-HT 5A , 5-HT 5B , 5-HT 6 , and 5-HT 7 , respectively. Methiothepin exhibits high affinity at 5-HT 2A , 5HT 2B , and 5HT 2C with pK i s of 8.50, 8.68, and 8.35, respectively.
安全信息
| WGK Germany | 3 |
|---|