Log in | Join Free | china | japan | germany

1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)-

Request For Quotation
1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Suppliers list
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:ZNL-02-096
CAS:2414418-49-6
Purity:98% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel: +86-18341751992 +86-15382112998
Email: 757984502@qq.com
Products Intro: Product Name:ZNL-02-096
CAS:2414418-49-6
Purity:98 Package:500mg；1g；5g；10g；25g Remarks:Provide customized services
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:ZNL-02-096
CAS:2414418-49-6
Purity:98% Package:5mg;10mg;25mg
Company Name: Shanghai Han-Xiang Chemical Co., Ltd.  
Tel: 15971444841
Email: amber@biochempartner.com
Products Intro: Product Name:ZNL-02-096
CAS:2414418-49-6
Purity:98% HPLC LCMS Package:100G;1KG
Company Name: ShangHai ChuanQian Chemcial Technique Centre  
Tel: 15869524721
Email: 3525679403@qq.com
Products Intro: CAS:2414418-49-6
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,10G
1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Basic information
Product Name:1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
Synonyms:1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)-;Pomalidomide-C3-adavosertib
CAS:2414418-49-6
MF:C42H45N11O6
MW:799.88
EINECS:
Product Categories:
Mol File:2414418-49-6.mol
1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Structure
1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties
density 1.409±0.06 g/cm3(Predicted)
solubility DMSO:39.99(Max Conc. mg/mL);50.0(Max Conc. mM)
pka10.75±0.40(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Usage And Synthesis
DescriptionZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC?) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand Pomalidomide. ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT-4 cells in vitro, ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and apoptosis. The compound shows antiproliferative effects in a panel of 300 cancer cell lines.
storageStore at -20°C
1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Preparation Products And Raw materials
Tag:1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)-(2414418-49-6) Related Product Information