Log in | Join Free | china | japan | germany

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 3,5-dihydro-2-[[(3R,5R)-1-methyl-5-[4-(phenylmethoxy)phenyl]-3-piperidinyl]amino]-3-(2-propen-1-yl)-

Request For Quotation
4H-Pyrrolo[3,2-d]pyrimidin-4-one, 3,5-dihydro-2-[[(3R,5R)-1-methyl-5-[4-(phenylmethoxy)phenyl]-3-piperidinyl]amino]-3-(2-propen-1-yl)- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:SETDB1-TTD-IN-1
CAS:2755823-12-0
Package:1 mg；10 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Zibo Hangyu Biotechnology Development Co., Ltd
Tel: +86-0533-2185556 +8617865335152
Email: Mandy@hangyubiotech.com
Products Intro: CAS:2755823-12-0
Purity:0.99 Package:5KG;1KG
Company Name: Shanghai Changyu Medical Technology Co. Ltd.  
Tel: +86-13301875428
Email: sales@changyuhe.com
Products Intro: CAS:2755823-12-0
Package:1g;5g
Company Name: Changzhou Bojia Biomedical Technology Co., Ltd.  
Tel: 2122619822
Email: czbjpharma@126.com
Products Intro: CAS:2755823-12-0
Purity:98% Package:100mg/1g/10g/100g/1kg
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Email: marketing@tsbiochem.com
Products Intro: Product Name:SETDB1-TTD-IN-1;SETDB1TTDIN1,SETDB1 TTD IN 1,SETDB-1-TTD-IN-1
CAS:2755823-12-0
Purity:99.05% Package:1 mg;10 mg;100 mg;2 mg;25 mg;5 mg
4H-Pyrrolo[3,2-d]pyrimidin-4-one, 3,5-dihydro-2-[[(3R,5R)-1-methyl-5-[4-(phenylmethoxy)phenyl]-3-piperidinyl]amino]-3-(2-propen-1-yl)- Basic information
Product Name:4H-Pyrrolo[3,2-d]pyrimidin-4-one, 3,5-dihydro-2-[[(3R,5R)-1-methyl-5-[4-(phenylmethoxy)phenyl]-3-piperidinyl]amino]-3-(2-propen-1-yl)-
Synonyms:4H-Pyrrolo[3,2-d]pyrimidin-4-one, 3,5-dihydro-2-[[(3R,5R)-1-methyl-5-[4-(phenylmethoxy)phenyl]-3-piperidinyl]amino]-3-(2-propen-1-yl)-;SETDB1-TTD-IN-1;SETDB1TTDIN1,SETDB1 TTD IN 1,SETDB-1-TTD-IN-1
CAS:2755823-12-0
MF:C28H31N5O2
MW:469.58
EINECS:
Product Categories:
Mol File:2755823-12-0.mol
4H-Pyrrolo[3,2-d]pyrimidin-4-one, 3,5-dihydro-2-[[(3R,5R)-1-methyl-5-[4-(phenylmethoxy)phenyl]-3-piperidinyl]amino]-3-(2-propen-1-yl)- Structure
4H-Pyrrolo[3,2-d]pyrimidin-4-one, 3,5-dihydro-2-[[(3R,5R)-1-methyl-5-[4-(phenylmethoxy)phenyl]-3-piperidinyl]amino]-3-(2-propen-1-yl)- Chemical Properties
Boiling point 664.2±65.0 °C(Predicted)
density 1.24±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light, stored under nitrogen
solubility DMSO : 125 mg/mL (266.20 mM; Need ultrasonic)
pka14.81±0.20(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
4H-Pyrrolo[3,2-d]pyrimidin-4-one, 3,5-dihydro-2-[[(3R,5R)-1-methyl-5-[4-(phenylmethoxy)phenyl]-3-piperidinyl]amino]-3-(2-propen-1-yl)- Usage And Synthesis
Biological ActivitySETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD), with a Kd of 88 nM. SETDB1-TTD-IN-1 can be used for the research of biological functions and disease associations of SETDB1-TTD[1]. SETDB1-TTD-IN-1 shows some activity for 53BP1 and JMJD2A, with Kds of 4.3 μM and 86 μM, respectively. SETDB1-TTD-IN-1 does not show activity against 14 of the 16 tested tudor domains (Kd>100 μM)[1].SETDB1-TTD-IN-1 (2.5-40 μM) efficiently and dose-dependently stabilizes the SETDB1-TTD protein in HEK293T cells[1].SETDB1-TTD-IN-1 (2.5-40 μM; 24 h) significantly affected the expression of 72 genes in human acute monocytic leukemia THP-1 cells[1].
References[1]. Guo Y, et, al. Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew Chem Int Ed Engl. 2021 Apr 12;60(16):8760-8765.
4H-Pyrrolo[3,2-d]pyrimidin-4-one, 3,5-dihydro-2-[[(3R,5R)-1-methyl-5-[4-(phenylmethoxy)phenyl]-3-piperidinyl]amino]-3-(2-propen-1-yl)- Preparation Products And Raw materials
Tag:4H-Pyrrolo[3,2-d]pyrimidin-4-one, 3,5-dihydro-2-[[(3R,5R)-1-methyl-5-[4-(phenylmethoxy)phenyl]-3-piperidinyl]amino]-3-(2-propen-1-yl)-(2755823-12-0) Related Product Information