COMPSTATIN
| 中文名称 | COMPSTATIN |
|---|---|
| 中文同义词 | 坎普他汀, >98%;坎普他汀;COMPSTATIN游离态;化合物COMPSTATIN;2-((4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-10,13-双((1H-咪唑-4-基)甲基)-19-((1H-吲哚-3-基)甲基)-4-(((2S,3R)-1-氨基-3-羟基-1-氧代丁-2-基)氨基甲酰基)-34-((2S,3S)-2-氨基-3-甲基戊酰胺)-25-(3-氨基-3-氧代丙基)-7-(3-胍基丙基)-28,31-二异丙基-6,9,12,15,18,21,24,27,30,33-十氧代-1,2-二硫杂-5,8,11,14,17,20,23,26,29,32-十氮杂环三十五烷-22-基)乙酸 |
| 英文名称 | Compstatin |
| 英文同义词 | H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2;Compstatin;H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2, (Disulfide bond);Compstatin trifluoroacetate salt H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 trifluoroacetate salt (Disulfide bond);Compstatin,ICVVQDWGHHRCT, >98%;L-Threoninamide, L-isoleucyl-L-cysteinyl-L-valyl-L-valyl-L-glutaminyl-L-α-aspartyl-L-tryptophylglycyl-L-histidyl-L-histidyl-L-arginyl-L-cysteinyl-, cyclic (2→12)-disulfide;Compstatin，ICVVQDWGHHRCT;Complement System,Inhibitor,Compstatin,inhibit |
| CAS号 | 206645-99-0 |
| 分子式 | C66H99N23O17S2 |
| 分子量 | 1550.77 |
| EINECS号 | |
| 相关类别 | 多肽;目录多肽 |
| Mol文件 | 206645-99-0.mol |
| 结构式 |  |
COMPSTATIN 性质
| 密度 | 1.56±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 酸度系数(pKa) | 4.00±0.10(Predicted) |
| 水溶解性 | Soluble to 2 mg/ml in sterile water |
| 序列 | H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2(Disulfide bridge: Cys2-Cys11) |
Compstatin exhibits an in vitro half-life in human blood of about2 hr.
In solution, compstatin forms a β-turn at residues Gln-5–Gly-8 with the disulfide bridge Cys-2–Cys12, residues Ile-1–Val-4, and Thr-13, forming a hydrophobic cluster.
Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures.
Compstatin is stable in baboon plasma for more than 24 h.
Pig xenografts survival is significantly longer in the Compstatin perfused group than in the control group.
| Animal Model: | Juvenile baboons ( P. Anubis ) weighing 10.5-28.8 kg. |
| Dosage: | 50, 25 mg/kg 60 min after heparin and 2 min before protamine. |
| Administration: | A bolus injection. |
| Result: | Completely inhibited complement activation induced by heparin–protamine complexes. |
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-P1036 | COMPSTATIN Compstatin | 206645-99-0 | 500μg | 650元 |
| 2024/04/30 | HY-P1036 | COMPSTATIN Compstatin | 206645-99-0 | 1mg | 900元 |